Laboratories

 

Laboratory of Population Studies

Contacts

 

Head of Laboratory

Chief researcher

Prof. Habil.Dr. Abdonas Tamošiūnas

Phone: +370 37 302885
E-mail: abdonas.tamosiunas@lsmuni.lt

 

 Personnel:

 Gailutė Bernotienė dr., senior researcher

Vilija Malinauskienė dr., senior researcher

Eglė Milinavičienė dr., researcher

Irena Milvidaitė dr., senior researcher,

Agnė Brazienė, junior reseacher

Virginija Dulskienė dr.,senior researcher

Dalia Lukšienė dr., senior researcher

Ričardas Radišauskas dr., senior researcher,

Daina Krančiukaitė-Butylkinienė dr., senior researcher

Renata Kučienė dr., senior researcher

Jūratė Medžionienė, senior engineer programmer

Domininka Šidlauskienė, senior engineer programmer

Dalia Virvičiūtė, engineer programmer

Kristina Jurėnienė, engineer programmer

Violeta Kapustinskienė, senior laboratory assistant

Zofija Ramašauskienė senior laboratory assistant

Diana Skarupskienė, senior laboratory assistant

Anastazija Kižienė, laboratory assistant

Loreta Paškevičienė, laboratory assistant

Vita Plieskienė, laboratory assistant

Vida Sabeckienė, laboratory assistant

Lilija Lubienė, operator

Jolanta Siaurusevičiūtė, operator

 

Main activities of laboratory:

1. Epidemiology of ischaemic heart disease and risk factors, quality of life, mental health.

2. Population registers of ischaemic heart disease (acute myocardial infarction) and strokei.

3. Influence of environmental and genetic factors on health in children population.

 

 Laboratory of Population studies operating principles:

Laboratory workers constantly renew their knowledge of raising qualification.

Research must be carried on time, high-quality and in compliance with the highest EU standards.

Results of research studies should be published in Lithuanian and international scientific journals and also presented at conferences.

Laboratory workers must carry out academic activities, sharing of experience and knowledge.

 

 International projects

- CHANCES-Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (2010-2015)

- Project SOR S/340006/01 (project by National Institute for Public Health and the Environment, Netherlands, and LUHS, Lithuania) (2011-2014)

- EU-funded “Horizon 2020” project ATHLOS “Ageing trajectories of health longitudinal opportunities and synergies” (2015-2020)

 

The Laboratory of Population studies carries two projects granted by Lithuanian Research Council (2015-2018 yrs.) 

 

Main publications (2018-2013):

 2018 -2017

1. Associations between high birth weight, being large for gestational age, and high blood pressure among adolescents: a cross-sectional study / Renata Kuciene, Virginija Dulskiene, Jurate Medzioniene // European journal of nutrition. Darmstadt, Germany: Steinkopff. ISSN 1436-6207. 2018, vol. 57, no. 1, p. 373-381. Science Citation Index Expanded (Web of Science); MEDLINE; 1. Internet access:
2. The Influence of proximity to city parks and major roads on the development of arterial hypertension / Agnė Brazienė, Jonė Venclovienė, Abdonas Tamošiūnas, Audrius Dėdelė, Dalia Lukšienė, Ričardas Radišauskas // Scandinavian journal of public health. London: Sage Publications. ISSN 1403-4948. 2018, vol. 00, no. 00, p. 00-00. Science Citation Index Expanded (Web of Science); MEDLINE; 1.179.  Internet access:
   
3.  Relationship of meteorological factors and acute stroke events in Kaunas (Lithuania) in 2000–2010 / Laura Tamasauskiene, Daiva Rastenyte, Ricardas Radisauskas, Abdonas Tamosiunas, Domantas Tamasauskas, Vidmantas Vaiciulis, Daina Kranciukaite-Butylkiniene, Egle Milinaviciene // Environmental science and pollution research international. Heidelberg: Springer. ISSN 0944-1344. 2017, vol. 24, no. 10, p. 9286-9293. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1. Internet access:
4. Self-rated health and all-cause and cause-specific mortality of older adults: Individual data meta-analysis of prospective cohort studies in the CHANCES Consortium / Christina Bamia, Philippos Orfanos, Hendrik Juerges, Ben Schöttker, Hermann Brenner, Roberto Lorbeer, Mette Aadahl, Charles E. Matthews, Eleni Klinaki, Michael Katsoulis, Pagona Lagiou, H.B(as). Bueno-de-Mesquita, Sture Eriksson, Ute Mons, Kai-Uwe Saum, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Sofia Malyutina, Julian Gardiner, Anne Peasey, Lisette CPGM de Groot, Tom Wilsgaard, Paolo Boffetta, Antonia Trichopoulou, Dimitrios Trichopoulos // Maturitas. Limerick: Elsevier/North Holland Biomedical Press. ISSN 0378-5122. 2017, vol. 103, p. 37-44. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.196. Internet access:
5. Assessment of coronary care management and hospital mortality from ST-segment elevation myocardial infarction in the Kazakhstan population: Data from 2012 to 2015 / Zhanar Akimbaeva, Zhumagali Ismailov, Aikan A. Akanov, Ričardas Radišauskas, Žilvinas Padaiga // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2017, vol. 53, no. 1, p. 58-65. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.4.  Internet access:
6. Bullying behavior and mental health in healthcare and educational sectors in Kaunas, Lithuania / Lina Bernotaite, Vilija Malinauskiene, Palmira Leisyte // Medycyna pracy. Lodz: Nofer Institute of Occupational Medicine. (Original paper). ISSN 0465-5893. 2017, vol. 68, no. 3, p. 1-8. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; DOAJ; Scopus; 0.667.  Internet access:
7. Workplace bullying and mental health among teachers in relation to psychosocial job characteristics and burnout / Lina Bernotaite, Vilija Malinauskiene // International journal of occupational medicine and environmental health. Lodz: Nofer Institute of Occupational Medicine. (Original paper). ISSN 1232-1087. 2017, vol. 30, no. 4, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.866.  Internet access:
8. Traditional risk factors of acute coronary syndrome in four different male populations – total cholesterol value does not seem to be relevant risk factor / J. A. Hubacek, V. Stanek, M. Gebauerova, V. Adamkova, V. Lesauskaite, D. Zaliaduonyte-Peksiene, A. Tamosiunas, A. Supiyev, A. Kossumov, A. Zhumadilova, J. Pitha // Physiological research. Prague: Institute of Physiology of the Czech Academy of Sciences. ISSN 0862-8408. 2017, vol. 66, suppl. 1, p. S121-S128. Science Citation Index Expanded (Web of Science); 0.445.  Internet access:
9. SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area / Daiva Stanislovaitiene, Dalia Zaliuniene, Algimantas Krisciukaitis, Robertas Petrolis, Alina Smalinskiene, Vita Lesauskaite, Abdonas Tamosiunas, Vaiva Lesauskaite // Ophthalmic genetics. London: Informa Healthcare. ISSN 1381-6810. 2017, vol. 38, no. 3, p. 233-237. Science Citation Index Expanded (Web of Science); MEDLINE; 0.65.  Internet access:
10. Combined effect of educational status and cardiovascular risk factors on the incidence of coronary heart disease and stroke in European cohorts: Implications for prevention / Giovanni Veronesi, Hugh Tunstall-Pedoe, Marco M Ferrario, Frank Kee, Kari Kuulasmaa, Lloyd E Chambless, Philippe Amouyel, Dominique Arveiler, Martin Bobak, Jean Ferrieres, Simona Giampaoli, Torben Jørgensen, Annette Peters, Veikko Salomaa, Stefan Soderberg, Abdonas Tamosiunas, Giancarlo Cesana; for the MORGAM Project // European journal of preventive cardiology. London: SAGE Publications. (Original scientific paper). ISSN 2047-4873. 2017, vol. 24, no. 4, p. 437-445. Science Citation Index Expanded (Web of Science); MEDLINE; 0.256.  Internet access:
11. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants / NCD Risk Factor Collaboration (NCD-RisC) : Bin Zhou, [...], Gailute Bernotiene, Virginija Dulskiene, Jurate Klumbiene, Renata Kuciene, Dalia Luksiene, Jurate Medzioniene, Janina Petkeviciene, Ricardas Radisauskas, Abdonas Tamosiunas, [...] // Lancet. London: Lancet Publishing Group. ISSN 0140-6736. 2017, vol. 389, no. 10064, p. 37-55. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1.212.  Internet access:
12. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study / Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-Hunter, [...], Abdonas Tamosiunas, [...]; LifeLines Cohort study group; UCLEB consortium, [...] // Lancet. Diabetes & endocrinology. London: Elsevier. ISSN 2213-8587. 2017, vol. 5, no. 2, p. 97-105. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.441.  Internet access:
13. Link between healthy lifestyle and psychological well-being in Lithuanian adults aged 45-72: a cross-sectional study / Laura Sapranaviciute-Zabazlajeva, Dalia Luksiene, Dalia Virviciute, Martin Bobak, Abdonas Tamosiunas // BMJ open. London: BMJ Publishing Group. (Research). ISSN 2044-6055. 2017, vol. 7, no. 4, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; CAB Abstracts; Global Health (CABI); Scopus; DOAJ; 1.039.  Internet access:
14. Impact of perceived control on all-cause and cardiovascular disease mortality in three urban populations of Central and Eastern Europe: the HAPIEE study / Magdalena Kozela, Andrzej Pająk, Agnieszka Micek, Agnieszka Besala, Ruzena Kubinova, Sofia Malyutina, Abdonas Tamosiunas, Hynek Pikhart, Anne Peasey, Yuri Nikitin, Michael Marmot, Martin Bobak // Journal of epidemiology and community health. London: BMJ Publishing Group. ISSN 0143-005X. 2017, vol. 71, iss. 8, p. 771-778. Science Citation Index Expanded (Web of Science); MEDLINE; 0.204.  Internet access:
15.  An optimal ultrasonographic diagnostic test for early gout: A prospective controlled study / Eleonora Norkuviene, Mykolas Petraitis, Indre Apanaviciene, Dalia Virviciute, Asta Baranauskaite // Journal of international medical research. London: Sage Publications. (Clinical report). ISSN 1473-2300. 2017, vol. 45, no. 4, p. 1417-1429. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; Scopus; 0.346.  Internet access:
16. Education and coronary heart disease: mendelian randomisation study / Taavi Tillmann, Julien Vaucher, Aysu Okbay, Hynek Pikhart, Anne Peasey, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Sofia Malyutina, Fernando Pires Hartwig, Krista Fischer, Giovanni Veronesi, Tom Palmer, Jack Bowden, George Davey Smith, Martin Bobak, Michael V Holmes // BMJ : British medical journal. London: BMJ Publishing Group. (Research). ISSN 1756-1833. 2017, vol. 358, p. 1-10. Science Citation Index Expanded (Web of Science); MEDLINE; 0.25. Internet access:
17. Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents / Sandrita Simonyte, Renata Kuciene, Jurate Medzioniene, Virginija Dulskiene, Vaiva Lesauskaite // BMC medical genetics. London: BioMed Central. (Research article). ISSN 1471-2350. 2017, vol. 18, no. 1, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; Scopus; 1.  Internet access:
18. Determinants of social inequalities in stroke incidence across Europe: a collaborative analysis of 126 635 individuals from 48 cohort studies / Marco M Ferrario, Giovanni Veronesi, Frank Kee, Lloyd E Chambless, Kari Kuulasmaa, Torben Jørgensen, Philippe Amouyel, Dominique Arveiler, Martin Bobak, Giancarlo Cesana, Wojciech Drygas, Jean Ferrieres, Simona Giampaoli, Licia Iacoviello, Yuri Nikitin, Andrzej Pajak, Annette Peters, Veikko Salomaa, Stefan Soderberg, Abdonas Tamosiunas, Tom Wilsgaard, Hugh Tunstall-Pedoe; on behalf of the MORGAM Project // Journal of epidemiology and community health. London: BMJ Publishing Group. (Research report). ISSN 0143-005X. 2017, vol. 71, iss. 12, p. 1210-1216. Science Citation Index Expanded (Web of Science); MEDLINE; 0.218.  Internet access:
19. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults / NCD Risk Factor Collaboration (NCD-RisC) : Leandra Abarca-Gómez, [...], Virginija Dulskiene, Juratė Klumbiene, Renata Kuciene, Dalia Luksiene, Jurate Medzioniene, Janina Petkeviciene, Ausra Petrauskiene, Ricardas Radisauskas, Abdonas Tamosiunas, [...] // Lancet. London: Lancet Publishing Group. ISSN 0140-6736. 2017, vol. 390, no. 10113, p. 2627-2642. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1.342.  Internet access:
20. Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development / Diana Žaliaduonytė-Pekšienė, Vaiva Lesauskaitė, Rasa Liutkevičienė, Vytenis Tamakauskas, Vilius Kviesulaitis, Giedrė Šinkūnaitė-Maršalkienė, Sandrita Šimonytė, Simonita Mačiulskytė, Eglė Tamulevičiūtė-Prascienė, Olivija Gustienė, Abdonas Tamošiūnas, Remigijus Žaliūnas // Journal of the renin-angiotensin-aldosterone system. London: Sage. (Original article). ISSN 1470-3203. 2017, vol. 18, no. 4, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 0.433.  Internet access:
21. Does MMP-9 gene polymorphism play a role in pituitary adenoma development? / Brigita Glebauskiene, Rasa Liutkeviciene, Alvita Vilkeviciute, Loresa Kriauciuniene, Silvija Jakstiene, Egle Zlatkute, Abdonas Tamosiunas, Reda Zemaitiene, Paulina Vaitkiene, Dalia Zaliuniene // Disease markers. New York: Hindawi Publishing Corporation. (Research article). ISSN 0278-0240. 2017, vol. 2017, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.2.  Internet access:
22. The Prognostic value of combined smoking and alcohol consumption habits for the estimation of cause-specific mortality in middle-age and elderly population: Results from a long-term cohort study in Lithuania / Dalia Luksiene, Abdonas Tamosiunas, Dalia Virviciute, Ricardas Radisauskas // BioMed research international. New York: Hindawi Publishing Corporation. (Research article). ISSN 2314-6133. 2017, vol. 2017, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; Scopus; 1.414.  Internet access:
23. Psychosocial and socioeconomic determinants of cardiovascular mortality in Eastern Europe: A multicentre prospective cohort study / Taavi Tillmann, Hynek Pikhart, Anne Peasey, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Sofia Malyutina, Andrew Steptoe, Mika Kivimäki, Michael Marmot, Martin Bobak // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2017, vol. 14, no. 12, 1-20. Prieiga per internetą: <https://www.ncbi.nlm.nih.gov/pubmed/29211726>. [Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; 0.223.  Internet access: 
24. Investigation of TGFβR2 SNP rs4522809, Osteopontin, TGF β1 and their association with dilatative pathology of ascending thoracic aorta / Zivile Staneviciute, Ramune Sepetiene, Ingrida Grabauskyte, Vaiva Patamsyte, Vaiva Lesauskaite // Cytokine. Oxford: Elsevier. ISSN 1043-4666. 2017, vol. 00, no. 00, p. 00-00. Science Citation Index Expanded (Web of Science); MEDLINE; 0.8.  Internet access:
25. Leisure-time physical inactivity and psychological distress in female dominated occupations in Lithuania / Vilija Malinauskiene, Romualdas Malinauskas, Mindaugas Malinauskas // Women & health. Philadelphia: Taylor & Francis. (Original articles). ISSN 0363-0242. 2017, vol. 00, no. 00, p. 00-00. Science Citation Index Expanded (Web of Science); MEDLINE; CAB Abstracts; IndexCopernicus; Scopus; 0.577.  Internet access:

2016  

1. Associations of morbidity and mortality from coronary heart disease with heliogeophysical factors / Vidmantas Vaičiulis, Ričardas Radišauskas, Rūta Ustinavičienė, Gintarė Kalinienė, Abdonas Tamošiūnas // Environmental science and pollution research international. Berlin: Springer. ISSN 0944-1344. 2016, vol. 23, no. 18, p. 18630-18638. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.566. Internet access:
2. Alcohol, drinking pattern and all-cause, cardiovascular and alcohol-related mortality in Eastern Europe / Martin Bobak, Sofia Malyutina, Pia Horvat, Andrzej Pajak, Abdonas Tamosiunas, Ruzena Kubinova, Galina Simonova, Roman Topor-Madry, Anne Peasey, Hynek Pikhart, Michael G. Marmot // European journal of epidemiology. Dordrecht: Kluwer Academic Publishers. (Mortality). ISSN 0393-2990. 2016, vol. 31, no. 1, p. 21-30. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; EMBASE; Chemical Abstracts Service (CAS); Google Scholar; EBSCO; CSA; CAB International; AGRICOLA; Biological Abstracts; BIOSIS; 0.223. Internet access:
3. Hypertension, serum lipids and cancer risk: A review of epidemiological evidence / Ričardas Radišauskas, Irena Kuzmickienė, Eglė Milinavičienė, Rūta Everatt // Medicina. Wrocław: Elsevier. (Review). ISSN 1010-660X. 2016, vol. 52, no. 2, p. 89-98. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.707. Internet access:
4. Problematic computer game use as expression of Internet addiction and its association with self-rated health in the Lithuanian adolescent population / Ruta Ustinavičienė, Lina Škėmienė, Dalia Lukšienė, Ričardas Radišauskas, Gintarė Kalinienė, Paulius Vasilavičius // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2016, vol. 52, no. 3, p. 199-204. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.333. Internet access:
5. Lack of association between NYD-SP18 variant and obesity. The Health alcohol and psychosocial factors in Eastern Europe Study / Jaroslav A. Hubacek, Hynek Pikhart, Ruzena Kubinova, Anne Peasey, Sofia Malyutina, Andrzej Pajak, Abdonas Tamosiunas, Martin Bobak // Annals of nutrition & metabolism. Basel ; New York: Karger. ISSN 0250-6807. 2016, vol. 68, no. 4, p. 244-248. Science Citation Index Expanded (Web of Science); MEDLINE; 0.306. Internet access:
6. Blood-based oxidative stress markers and cognitive performance in early old age: The HAPIEE Study / Pia Horvat, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Ben Schöttker, Hynek Pikhart, Anne Peasey, Magdalena Kozela, Eugene Jansen, Archana Singh-Manoux, Martin Bobak // Dementia and geriatric cognitive disorders. Basel ; New York: Karger. (Original research article). ISSN 1420-8008. 2016, vol. 42, no. 5-6, p. 297-309. Science Citation Index Expanded (Web of Science); MEDLINE; 0.273. Internet access: 
7. Role of MMP-2 (-1306 C/T) polymorphism in age- related macular degeneration / Rasa Liutkeviciene, Vaiva Lesauskaite, Diana Zaliaduonyte-Peksiene, Giedre Sinkunaite-Marsalkiene, Dalia Zaliuniene, Vaida Mizariene, Olivija Gustiene, Vytautas Jasinskas, Abdonas Tamosiunas // Ophthalmic genetics. London: Informa Healthcare. (Research report). ISSN 1381-6810. 2016, vol. 37, no. 2, p. 170-176. Science Citation Index Expanded (Web of Science); MEDLINE; 0.385. Internet access:
8. Serum folate, vitamin B-12 and cognitive function in middle and older age: the HAPIEE study / Pia Horvat, Julian Gardiner, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Ben Schöttker, Hynek Pikhart, Anne Peasey, Eugene Jansen, Martin Bobak // Experimental gerontology. Tarrytown Ny: Elsevier Science. ISSN 0531-5565. 2016, vol. 76, no. April, p. 33-38. Science Citation Index Expanded (Web of Science); MEDLINE; EMBASE; BIOSIS; Scopus; 0.265.  Internet access:
9. Educational class inequalities in the incidence of coronary heart disease in Europe / Giovanni Veronesi, Marco M Ferrario, Kari Kuulasmaa, Martin Bobak, Lloyd E Chambless, Veikko Salomaa, Stefan Soderberg, Andrzej Pajak, Torben Jørgensen, Philippe Amouyel, Dominique Arveiler, Wojciech Drygas, Jean Ferrieres, Simona Giampaoli, Frank Kee, Licia Iacoviello, Sofia Malyutina, Annette Peters, Abdonas Tamosiunas, Hugh Tunstall-Pedoe, Giancarlo Cesana // Heart. London: BMJ Publishing Group. (Cardiac risk factors and prevention). ISSN 1355-6037. 2016, vol. 102, no. 12, p. 958-965. Science Citation Index Expanded (Web of Science); MEDLINE; 0.218. Internet access:
10. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants / NCD Risk Factor Collaboration (NCD-RisC) : Mariachiara Di Cesare, [...], Gailute Bernotiene, Dalia Luksiene, Ricardas Radisauskas, Abdonas Tamosiunas, [...] // Lancet. London: Lancet Publishing Group. ISSN 0140-6736. 2016, vol. 387, no. 10026, p. 1377-1396. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1.386. Internet access:
11. Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium / José Manuel Ordóñez-Mena, Ben Schöttker, UteMons, Mazda Jenab, Heinz Freisling, Bas Bueno-de-Mesquita, Mark G. O’Doherty, Angela Scott, Frank Kee, Bruno H. Stricker, Albert Hofman, Catherine E. de Keyser, Rikje Ruiter, Stefan Söderberg, Pekka Jousilahti, Kari Kuulasmaa, Neal D. Freedman, Tom Wilsgaard, Lisette CPGM de Groot, Ellen Kampman, Niclas Håkansson, Nicola Orsini, Alicja Wolk, Lena Maria Nilsson, Anne Tjønneland, Andrzej Pająk, Sofia Malyutina, Růžena Kubínová, Abdonas Tamosiunas, Martin Bobak, Michail Katsoulis, Philippos Orfanos, Paolo Boffetta, Antonia Trichopoulou, Hermann Brenner; on behalf of the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States. (CHANCES) // BMC medicine. [London]: BioMed Central. (Research article). ISSN 1741-7015. 2016, vol. 14, no. 1, p. 1-15. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; 0.148. Internet access:
12. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants / NCD Risk Factor Collaboration (NCD-RisC): Bin Zhou, [...], Dalia Luksiene, [...], Ricardas Radisauskas, [...], Abdonas Tamosiunas, [...] // Lancet. London: Lancet Publishing Group. ISSN 0140-6736. 2016, vol. 387, no. 10027, p. 1513-1530. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1.061. Internet access:
13. Trends in major risk factors and mortality from main non-communicable diseases in Lithuania, 1985-2013 / Abdonas Tamosiunas, Jurate Klumbiene, Janina Petkeviciene, Ricardas Radisauskas, Olga Vikhireva, Dalia Luksiene, Dalia Virviciute // BMC public health. London: BioMed Central. (Research article). ISSN 1471-2458. 2016, vol. 16, p. 1-10. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 1.278. Internet access:
14. A century of trends in adult human height / NCD Risk Factor Collaboration (NCD-RisC) : James Bentham (Imperial College London, UK), [...], Gailute Bernotiene, Jurate Klumbiene, Dalia Luksiene, Janina Petkeviciene, Ricardas Radisauskas, Abdonas Tamosiunas, [...] // eLife. Cambridge, UK: eLife Sciences Publications. (Research article). ISSN 2050-084X. 2016, vol. 5, p. 1-29. Science Citation Index Expanded (Web of Science); MEDLINE; 0.808. Internet access:
15. Trends in the attack rates, incidence, and mortality of stroke during 1986-2012: data of Kaunas (Lithuania) Stroke Registry / Ricardas Radisauskas, Vilija Malinauskiene, Egle Milinaviciene, Daina Kranciukaite-Butylkiniene, Abdonas Tamosiunas, Gailute Bernotiene, Dalia Luksiene, Zemyna Milasauskiene, Diana Sopagiene, Daiva Rastenyte // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2016, vol. 11, no. 4, p. 1-14. Science Citation Index Expanded (Web of Science); MEDLINE; AGRICOLA; DOAJ; Scopus; 1.4. Internet access:

2015  

1. Biomarkers of oxidative stress and redox status in a short-term low-dosed multivitamin and mineral supplementation study in two human age groups / Jansen E, Beekhof P, Tamosiunas A, Luksiene D, Baceviciene M // Biogerontology. Dordrecht ; Boston: Kluwer Academic. (Research article). ISSN 1389-5729. 2015, vol. 16, no. 5, p. 645-653. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; EMBASE; Chemical Abstracts Service (CAS); Google Scholar; ProQuest; Health Reference Center Academic; 0.849. Internet access:
2. Smoking and All-cause Mortality in Older Adults: Results From the CHANCES Consortium / Müezzinler A, Mons U, Gellert C, Schöttker B, Jansen E, Kee F, O'Doherty MG, Kuulasmaa K, Freedman ND, Abnet CC, Wolk A, Håkansson N, Orsini N, Wilsgaard T, Bueno-de-Mesquita B, van der Schouw YT, Peeters PH, de Groot LC, Peters A, Orfanos P, Linneberg A, Pisinger C, Tamosiunas A, Baceviciene M, Luksiene D, Bernotiene G, Jousilahti P, Petterson-Kymmer U, Jansson JH, Söderberg S, Eriksson S, Jankovic N, Sánchez MJ, Veronesi G, Sans S, Drygas W, Trichopoulou A, Boffetta P, Brenner H // American journal of preventive medicine. Amsterdam: Elsevier Science. ISSN 0749-3797. 2015, vol. 49, no. 5, p. e53-e63. Science Citation Index Expanded (Web of Science); MEDLINE; BIOSIS; International Nursing Index; EMBASE; Scopus; 0.533. Internet access:
3. Impact of hypertension on postreperfusion left ventricular recovery in patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease / Edvardas Vaicekavičius, Donatas Vasiliauskas, Ramūnas Navickas, Irena Milvidaitė, Ramūnas Unikas, Jonė Venclovienė, Raimondas Kubilius // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2015, vol. 51, no. 1, p. 38-45. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.808. Internet access:
4. The Role of matrix metalloproteinases polymorphisms in age-related macular degeneration / Liutkeviciene R, Lesauskaite V, Sinkunaite-Marsalkiene G, Zaliuniene D, Zaliaduonyte-Peksiene D, Mizariene V, Gustiene O, Jasinskas V, Jariene G, Tamosiunas A // Ophthalmic genetics. London: Informa Healthcare. ISSN 1381-6810. 2015, vol. 36, no. 2, p. 149-155. Science Citation Index Expanded (Web of Science); MEDLINE; 0.52. Internet access:
5. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials / Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen E L Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul C D Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene C W Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, [et all.] ; DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium // Lancet. London: Lancet Publishing Group. ISSN 0140-6736. 2015, vol. 385, no. 9965, p. 351–361. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.268. Internet access:
6. FBN1 polymorphisms in patients with the dilatative pathology of the ascending thoracic aorta / Lesauskaite V, Sepetiene R, Jariene G, Patamsyte V, Zukovas G, Grabauskyte I, Stanioniene Z, Sirmenis R, Benetis R // European journal of cardio-thoracic surgery. Kidlington, Oxford, UK: Elsevier Science. ISSN 1010-7940. 2015, vol. 47, no. 4, p. e124-e130. Science Citation Index Expanded (Web of Science); MEDLINE; 1.556. Internet access:
7. Effect of clinical factors and gene polymorphism of CYP2C19*2, *17 and CYP4F2*3 on early stent thrombosis / Kupstyte N, Zaliunas R, Tatarunas V, Skipskis V, Zaliaduonyte-Peksiene D, Grabauskyte I, Dovidaitiene D, Bumblauskas K, Gustiene O, Lesauskaite V // Pharmacogenomics. London: Future Medicine. (Research article). ISSN 1462-2416. 2015, vol. 16, no. 3, p. 181-189. Science Citation Index Expanded (Web of Science); MEDLINE; Biological Abstracts; BIOSIS Previews; Prous Science Integrity®; Scopus; 0.693. Internet access:
8. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium / Mons U, Müezzinler A, Gellert C, Schöttker B, Abnet CC, Bobak M, de Groot L, Freedman ND, Jansen E, Kee F, Kromhout D, Kuulasmaa K, Laatikainen T, O'Doherty MG, Bueno-de-Mesquita B, Orfanos P, Peters A, van der Schouw YT, Wilsgaard T, Wolk A, Trichopoulou A, Boffetta P, Brenner H; CHANCES consortium : [...] Migle Baceviciene, [...], Abdonas Tamošiūnas, [...] // BMJ : British medical journal. London: BMJ Publishing Group. (Research). ISSN 1756-1833. 2015, vol. 350, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; 0.392.Internet access :
9. Trends in out-of-hospital ischemic heart disease mortality for the 25-64 year old population of Kaunas, Lithuania, based on data from the 1988-2012 Ischemic Heart Disease Registry / Bernotiene G, Radisauskas R, Tamosiunas A, Milasauskiene Z // Scandinavian journal of public health. London: Sage Publications. (Original article). ISSN 1403-4948. 2015, vol. 43, no. 6, p. 648-656. Science Citation Index Expanded (Web of Science); MEDLINE; 1.5. Internet access:
10. Anthropometric trends and the risk of cardiovascular disease mortality in a Lithuanian urban population aged 45-64 years / Luksiene D, Tamosiunas A, Virviciute D, Bernotiene G, Peasey A // Scandinavian journal of public health. London: Sage Publications. (Original article). ISSN 1403-4948. 2015, vol. 43, no. 8, p. 882-889. Science Citation Index Expanded (Web of Science); MEDLINE; 1.6. Internet access:
11. Association of neck circumference and high blood pressure in children and adolescents: a case–control study / Renata Kuciene, Virginija Dulskiene, Jurate Medzioniene // BMC pediatrics. London: BioMed Central. (Research article). ISSN 1471-2431. 2015, vol. 15, p. 1-10. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1. Internet access:
12. Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data / Ben Schöttker, Hermann Brenner, Eugène HJM Jansen, Julian Gardiner, Anne Peasey, Růžena Kubínová, Andrzej Pająk, Roman Topor-Madry, Abdonas Tamosiunas, Kai-Uwe Saum, Bernd Holleczek, Hynek Pikhart, Martin Bobak // BMC medicine. [London]: BioMed Central. (Research article). ISSN 1741-7015. 2015, vol. 13, p. 1-15. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.231. Internet access:
13. Association between fibrillin1 polymorphisms (rs2118181, rs10519177) and transforming growth factor β1 concentration in human plasma / Ramune Sepetiene, Vaiva Patamsyte, Giedrius Zukovas, Giedre Jariene, Zita Stanioniene, Rimantas Benetis, Abdonas Tamosiunas, Vaiva Lesauskaite // Molecular medicine. Manhasset, NY: Feinstein Institute for Medical Research. ISSN 1076-1551. 2015, vol. 21, p. 735-738. Science Citation Index Expanded (Web of Science); MEDLINE; 1.516. Internet access:
14. The Prognostic value of family history for the estimation of cardiovascular mortality risk in men: results from a long-term cohort study in Lithuania / Abdonas Tamosiunas, Ricardas Radisauskas, Jurate Klumbiene, Gailute Bernotiene, Janina Petkeviciene, Dalia Luksiene, Dalia Virviciute, Vilija Malinauskiene, Olga Vikhireva, Vilius Grabauskas // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2015, vol. 10, no. 12, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; PyscINFO; AGRICOLA; Scopus; DOAJ; 1.2. Internet access:

2014 

1. Correlates of depressive symptoms in urban middle-aged and elderly Lithuanians / Sapranaviciute-Zabazlajeva L, Reklaitiene R, Tamosiunas A, Baceviciene M, Virviciute D, Peasey A // Social psychiatry and psychiatric epidemiology. Heidelberg: Springer. (Original paper). ISSN 0933-7954. 2014, vol. 49, no. 8, p. 1199-1207. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; PsycINFO; CSA; CAB International; Abstracts in Anthropology; Academic OneFile; Academic Search; CAB Abstracts; 0.943. Internet access:
2. Association between obesity and high blood pressure among Lithuanian adolescents: a cross-sectional study/ Dulskiene V, Kuciene R, Medzioniene J, Benetis R // Italian journal of pediatrics. London: BioMed Central. ISSN 1720-8424. 2014, vol. 40, no. 1, p. 1-18. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; IndexCopernicus; 1. Internet access:
3. Body mass index, cholesterol level and risk of lung cancer in Lithuanian men / Rūta Everatt, Dalia Virvičiūtė, Irena Kuzmickienė, Abdonas Tamošiūnas // Lung cancer. Amsterdam: Elsevier. ISSN 0169-5002. 2014, vol. 85, iss. 3, p. 361-365. Science Citation Index Expanded (Web of Science); MEDLINE; Current contents; EMBASE; Elsevier BIOBASE; Oncology Information Service; Scopus; 0.707. Internet access:
4. Trends of myocardial infarction morbidity and its associations with weather conditions / Ričardas Radišauskas, Gailutė Bernotienė, Miglė Bacevičienė, Rūta Ustinavičienė, Jolita Kirvaitienė, Daina Krančiukaitė-Butylkinienė // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2014, vol. 50, no. 3, p. 182-189. [Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 1.155. Internet access:
5. Workplace bullying and post-traumatic stress symptoms among family physicians in Lithuania: an occupation and region specific approach / Vilija Malinauskiene, Staale Einarsen // International journal of occupational medicine and environmental health. Lodz: Nofer Institute of Occupational Medicine. (Original paper). ISSN 1232-1087. 2014, vol. 27, no. 6, p. 919-932. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; 0.866. Internet access : 
6. Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene / Zaliaduonyte-Peksiene D, Simonyte S, Lesauskaite V, Vaskelyte J, Gustiene O, Mizariene V, Jurkevicius R, Jariene G, Tamosiunas A, Zaliunas R // Journal of the renin-angiotensin-aldosterone system : JRAAS. London: SAGE Publications. ISSN 1470-3203. 2014, vol. 15, no. 3, p. 286-293. Science Citation Index Expanded (Web of Science); MEDLINE; 0.866. Internet access:
7. SCORE performance in Central and Eastern Europe and former Soviet Union: MONICA and HAPIEE results / Vikhireva O, Pajak A, Broda G, Malyutina S, Tamosiunas A, Kubinova R, Simonova G, Skodova Z, Bobak M, Pikhart H // European heart journal. Oxford: Oxford University Press. (Clinical research). ISSN 0195-668X. 2014, vol. 35, no. 9, p. 571-577. Science Citation Index Expanded (Web of Science); MEDLINE; 0.265. Internet access:
8. Socioeconomic inequalities in all-cause mortality in the Czech Republic, Russia, Poland and Lithuania in the 2000s: findings from the HAPIEE Study / Vandenheede H, Vikhireva O, Pikhart H, Kubinova R, Malyutina S, Pajak A, Tamosiunas A, Peasey A, Simonova G, Topor-Madry R, Marmot M, Bobak M // Journal of epidemiology and community health. London: BMJ Publishing Group. ISSN 0143-005X. 2014, vol. 68, iss. 4, p. 297-303. Science Citation Index Expanded (Web of Science); MEDLINE; 0.236. Internet access:
9. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants / The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects): Randi Selmer, [...], Daiva Rastenyte, Abdonas Tamosiunas, [...] // Lancet. London: Lancet Publishing Group. ISSN 0140-6736. 2014, vol. 383, no. 9921, p. 970-983. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.577. Internet access:
10. Do other cardiovascular risk factors influence the impact of age on the association between blood pressure and mortality? The MORGAM Project / Vishram Julie K.K, Borglykke Anders, Andreasen Anne H, Jeppesen Jørgen, Ibsen Hans, Jørgensen Torben, Broda Grazyna, Palmieri Luigi. Giampaoli Simona, Donfrancesco Chiara, Kee Frank, Mancia Giuseppe, Cesana Giancarlo, Kuulasmaa Kari, Salomaa Veikko, Sans Susana, Ferrieres Jean, Tamosiunas Abdonas, Söderberg Stefan, Mcelduff Patrick, Arveiler Dominique, Pajak, Andrzej, Olsen Michael H // Journal of hypertension. London: Lippincott Williams & Wilkins. ISSN 0263-6352. 2014, vol. 32, no. 5, p. 1025-1033. Science Citation Index Expanded (Web of Science); MEDLINE; 0.184. Internet access:
11. Cigarette smoking, educational level and total and site-specific cancer: a cohort study in men in Lithuania / Everatt R, Kuzmickienė I, Virvičiūtė D, Tamošiūnas A // European journal of cancer prevention. London: Lippincott Williams & Wilkins. (Research paper). ISSN 0959-8278. 2014, vol. 23, no. 6, p. 579-586. Science Citation Index Expanded (Web of Science); MEDLINE; 0.707. Internet access :
12. Accessibility and use of urban green spaces, and cardiovascular health: findings from a Kaunas cohort study/ Tamosiunas A, Grazuleviciene R, Luksiene D, Dedele A, Reklaitiene R, Baceviciene M, Vencloviene J, Bernotiene G, Radisauskas R, Malinauskiene V, Milinaviciene E, Bobak M, Peasey A, Nieuwenhuijsen MJ // Environmental health : a global access science source. London: BioMed Central. (Research). ISSN 1476-069X. 2014, vol. 13, p. 1-11. Science Citation Index Expanded (Web of Science); MEDLINE; CABI; EmBiology; Scopus; 1.225. Internet access:
13.  Associations of short sleep duration with prehypertension and hypertension among Lithuanian children and adolescents: a cross-sectional study / Renata Kuciene, Virginija Dulskiene // BMC public health. London: BioMed Central. ISSN 1471-2458. 2014, vol. 14, p. 1-8. Science Citation Index Expanded (Web of Science); MEDLINE; Food Science and Technology Abstracts; Scopus; 1. Internet access:
14. Alcohol consumption and cognitive performance: a Mendelian randomisation study / Kumari M, Holmes MV, Dale CE, Hubacek J, Palmer TM, Pikhart H, Peasey A, Britton A, Horvat P, Kubinova R, Malyutina S, Pajak A, Tamosiunas A, Shanka A, Singh-Manoux A, Voevoda M, Kivimaki M, Hingorani AD, Marmot MG, Casas JP, Bobak M // Addiction. Oxford: Wiley-Blackwell. (Research report). ISSN 0965-2140. 2014, vol. 109, no. 9, p. 1462-1471. Science Citation Index Expanded (Web of Science); MEDLINE; 0.178. Internet access:
15. The Contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: The MORGAM Project Cohort Component / Ferrario MM, Veronesi G, Chambless LE, Tunstall-Pedoe H, Kuulasmaa K, Salomaa V, Borglykke A, Hart N, Söderberg S, Cesana G; for the MORGAM Project: [...], Tamosiunas A, Domarkiene S, Rastenyte D, Bernotiene G, Radisauskas R, Baceviciene M, Luksiene D, Malinauskiene V, Bernotaite L, [...] // Heart. London: BMJ Publishing Group. (Original article). ISSN 1355-6037. 2014, vol. 100, iss. 15, p. 1179-1187. Science Citation Index Expanded (Web of Science); MEDLINE; 1.165. Internet access:
16. Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries / Marti-Soler H, Gubelmann C, Aeschbacher S, Alves L, Bobak M, Bongard V, Clays E, de Gaetano G, Di Castelnuovo A, Elosua R, Ferrieres J, Guessous I, Igland J, Jørgensen T, Nikitin Y, O'Doherty MG, Palmieri L, Ramos R, Simons J, Sulo G, Vanuzzo D, Vila J, Barros H, Borglykke A, Conen D, De Bacquer D, Donfrancesco C, Gaspoz JM, Giampaoli S, Giles GG, Iacoviello L, Kee F, Kubinova R, Malyutina S, Marrugat J, Prescott E, Ruidavets JB, Scragg R, Simons LA, Tamosiunas A, Tell GS, Vollenweider P, Marques-Vidal P // Heart. London: BMJ Publishing Group. (Cardiac risk factors and prevention). ISSN 1355-6037. 2014, vol. 100 iss. 19, p. 1517-1523. Science Citation Index Expanded (Web of Science); MEDLINE; 0.123. Internet access:
17. Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States / Ben Schöttker, Rolf Jorde, Anne Peasey, Barbara Thorand, Eugène H J M Jansen, Lisette de Groot, Martinette Streppel, Julian Gardiner, José Manuèl Ordóñez-Mena, Laura Perna, Tom Wilsgaard, Wolfgang Rathmann, Edith Feskens, Ellen Kampman, Galatios Siganos, Inger Njølstad, Ellisiv Bøgeberg Mathiesen, Růžena Kubínová, Andrzej Pająk, Roman Topor-Madry, Abdonas Tamosiunas, Maria Hughes, Frank Kee, Martin Bobak, Antonia Trichopoulou, Paolo Boffetta, Hermann Brenner // BMJ : British medical journal. London: BMJ Publishing Group. (Research). ISSN 1756-1833. 2014, vol. 348, p. 1-15. Science Citation Index Expanded (Web of Science); MEDLINE; 0.157. Internet access:
18. Association of major cardiovascular risk factors with the development of acute coronary syndrome in Lithuania / Indrė Čeponienė, Diana Žaliaduonytė-Pekšienė, Olivija Gustienė, Abdonas Tamošiūnas and Remigijus Žaliūnas // European heart journal supplements : journal of the European Society of Cardiology : Highlights on Cardiovascular Health Systems in Transition : July 30, 2014 / Editor-in-Chief: Francisco Fernández-Avilés, [et al.] ; Edited by Raffaele Bugiardini and Lina Badimon ; European Society of Cardiology. Oxford: Oxford University Press. ISSN 1520-765X. 2014, vol. 16, suppl. A, p. A80-A83 : lent. MEDLINE.; Science Citation Index Expanded (Web of Science); SCISearch.; Research Alert.; Medical Documentation Service.; Current Contents/ Clinical Medicine.; Chemical Abstracts.; EMBASE.; Index Medicus.; 0.283. Internet access: 
19. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data / Michael V Holmes, Caroline E Dale, Luisa Zuccolo, Richard J Silverwood, Yiran Guo, Zheng Ye, David Prieto-Merino, Abbas Dehghan, Stella Trompet, Andrew Wong, Alana Cavadino, Dagmar Drogan, Sandosh Padmanabhan, Shanshan Li, Ajay Yesupriya, Maarten Leusink, Johan Sundstrom, Jaroslav A Hubacek, Hynek Pikhart, Daniel I Swerdlow, Andrie G Panayiotou, Svetlana A Borinskaya, Chris Finan, Sonia Shah, Karoline B Kuchenbaecker, Tina Shah, Jorgen Engmann, Lasse Folkersen, Per Eriksson, Fulvio Ricceri, Olle Melander, Carlotta Sacerdote, Dale M Gamble, Sruti Rayaprolu, Owen A Ross, Stela McLachlan, Olga Vikhireva, Ivonne Sluijs, Robert A Scott, Vera Adamkova, Leon Flicker, Frank M van Bockxmeer, Christine Power, Pedro Marques-Vidal, Tom Meade, Michael G Marmot, Jose M Ferro, Sofia Paulos-Pinheiro, Steve E Humphries, Philippa J Talmud, Irene Mateo Leach, Niek Verweij, Allan Linneberg, Tea Skaaby, Pieter A Doevendans, Maarten J Cramer, Pim van der Harst, Olaf H Klungel, Nicole F Dowling, Anna F Dominiczak, Meena Kumari, Andrew N Nicolaides, Cornelia Weikert, Heiner Boeing, Shah Ebrahim, Tom R Gaunt, Jackie F Price, Lars Lannfelt, Anne Peasey, Ruzena Kubinova, Andrzej Pajak, Sofia Malyutina, Mikhail I Voevoda, Abdonas Tamosiunas, Anke H Maitland-van der Zee, Paul E Norman, Graeme J Hankey, Manuela M Bergmann, Albert Hofman, Oscar H Franco, Jackie Cooper, Jutta Palmen, Wilko Spiering, Pim A de Jong, Diana Kuh, Rebecca Hardy, Andre G Uitterlinden, M Arfan Ikram, Ian Ford, Elina Hyppönen, Osvaldo P Almeida, Nicholas J Wareham, Kay-Tee Khaw, Anders Hamsten, Lise Lotte N Husemoen, Anne Tjønneland, Janne S Tolstrup, Eric Rimm, Joline W J Beulens, W M Monique Verschuren, N Charlotte Onland-Moret, Marten H Hofker, S Goya Wannamethee, Peter H Whincup, Richard Morris, Astrid M Vicente, Hugh Watkins, [et al.] // BMJ : British medical journal. London: BMJ Publishing Group. (Research). ISSN 1756-1833. 2014, vol. 349, p. 1-16. Science Citation Index Expanded (Web of Science); MEDLINE; 0.185. Internet access:
20. The Relationship of green space, depressive symptoms and perceived general health in urban population / Reklaitiene R, Grazuleviciene R, Dedele A, Virviciute D, Vensloviene J, Tamosiunas A, Baceviciene M, Luksiene D, Sapranaviciute-Zabazlajeva L, Radisauskas R, Bernotiene G, Bobak M, Nieuwenhuijsen MJ // Scandinavian journal of public health. London: Sage Publications. ISSN 1403-4948. 2014, vol. 42, no. 7, p. 669-676. Science Citation Index Expanded (Web of Science); MEDLINE; 1.507. Internet access:
21. Life course socioeconomic position and mid-late life cognitive function in Eastern Europe / Horvat P, Richards M, Malyutina S, Pajak A, Kubinova R, Tamosiunas A, Pikhart H, Peasey A, Marmot MG, Bobak M // Journals of gerontology. Series B, Psychological sciences and social sciences. Washington, DC: published on behalf of the Gerontological Society of America by Oxford University Press. ISSN 1079-5014. 2014, vol. 69, no. 3, p. 470-481. Science Citation Index Expanded (Web of Science); MEDLINE; 0.265. Internet access:
22. Does inclusion of education and marital status improve SCORE performance in Central and Eastern Europe and former Soviet Union? Findings from MONICA and HAPIEE cohorts / Vikhireva O, Broda G, Kubinova R, Malyutina S, Pająk A, Tamosiunas A, Skodova Z, Simonova G, Bobak M, Pikhart H // PLoS One. San Francisco: Public Library of Science. ISSN 1932-6203. 2014, vol. 9, no. 4, p. 1-11. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; AGRICOLA; PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; DOAJ; 0.283. Internet access:
23. Trends in prevalence of dyslipidaemias and the risk of mortality in lithuanian urban population aged 45-64 in relation to the presence of the dyslipidaemias and the other cardiovascular risk factors / Luksiene D, Tamosiunas A, Baceviciene M, Radisauskas R, Malinauskiene V, Peasey A, Bobak M // PLoS One. San Francisco: Public Library of Science. ISSN 1932-6203. 2014, vol. 9, no. 6, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; DOAJ; 1.237. Internet access:
    
24. Physical, behavioural and genetic predictors of adult hypertension: the findings of the Kaunas cardiovascular risk cohort study / Petkeviciene J, Klumbiene J, Simonyte S, Ceponiene I, Jureniene K, Kriaucioniene V, Raskiliene A, Smalinskiene A, Lesauskaite V // PLoS One. San Francisco: Public Library of Science. ISSN 1932-6203. 2014, vol. 9, no. 10, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Chemical Abstracts Service (CAS); PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; DOAJ; 0.577. Internet access:
25. Health factors and risk of all-cause, cardiovascular, and coronary heart disease mortality: findings from the MONICA and HAPIEE studies in Lithuania / Tamosiunas A, Luksiene D, Baceviciene M, Bernotiene G, Radisauskas R, Malinauskiene V, Kranciukaite-Butylkiniene D, Virviciute D, Peasey A, Bobak M // PLoS One. San Francisco: Public Library of Science. ISSN 1932-6203. 2014, vol. 9, no. 12, p. 1-15. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; AGRICOLA; PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; DOAJ; 1.131. Internet access:

2013  

1. Dose-response association between physical activity and metabolic syndrome / Migle Baceviciene, Dalia Ieva Luksiene, Vida Janina Cesnaitiene, Sandra Raubaite, Anne Peasey, Abdonas Tamosiunas // Central European journal of medicine. Berlin: Springer. (Research article). ISSN 1895-1058. 2013, vol. 8, iss. 2, p. 273-282. Science Citation Index Expanded (Web of Science); Global Health; IndexCopernicus; Scopus; 0.866. Internet access:
2. The Effect of atmospheric temperature and pressure on the occurrence of acute myocardial infarction in Kaunas / Ričardas Radišauskas, Vidmantas Vaičiulis, Rūta Ustinavičienė, Gailutė Bernotienė // Medicina. Kaunas: Lietuvos sveikatos mokslų universitetas. (Public health). ISSN 1010-660X. 2013, t. 49, Nr. 10, p. 447-452. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.5. Internet access:
3. The Relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project / V. Wietlisbach, P. Marques-Vidal, K. Kuulasmaa, J. Karvanen, F. Paccaud; WHO MONICA Project collab. : [...] J Bluzhas, S Domarkiene, A Tamosiunas, R Reklaitiene, [...] // Nutrition, metabolism, and cardiovascular diseases : NMCD. Amsterdam: Elsevier. ISSN 0939-4753. 2013, vol. 23, no. 5, p. 432-442. Science Citation Index Expanded (Web of Science); MEDLINE; 0.222. Internet access:
4. Smoking and other risk factors for pancreatic cancer: A cohort study in men in Lithuania / Irena Kuzmickiene, Ruta Everatt, Dalia Virviciute, Abdonas Tamosiunas, Ricardas Radisauskas, Regina Reklaitiene, Egle Milinaviciene // Cancer epidemiology. Amsterdam: Elsevier. ISSN 1877-7821. 2013, vol. 37, no. 2, p. 133-139. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.808. Internet access:
5. Consumption of alcohol and risk of cancer among men: a 30 year cohort study in Lithuania / Everatt R, Tamosiunas A, Virviciute D, Kuzmickiene I, Reklaitiene R // European journal of epidemiology. Dordrecht: Kluwer Academic Publishers. (Cancer). ISSN 0393-2990. 2013, vol. 28, no. 5, p. 383-392. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Chemical Abstracts Service (CAS); EBSCO; CSA; CAB International; AGRICOLA; Biological Abstracts; BIOSIS; 0.566. Internet access:
6. SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner / Stanislovaitiene D, Lesauskaite V, Zaliuniene D, Smalinskiene A, Gustiene O, Zaliaduonyte-Peksiene D, Tamosiunas A, Luksiene D, Petkeviciene J, Zaliunas R // Lipids in health and disease. [London]: BioMed Central. ISSN 1476-511X. 2013, vol. 12, p. 1-8. Science Citation Index Expanded (Web of Science); MEDLINE; CABI; Food Science and Technology Abstracts; Scopus; 0.693. Internet access: 
7. Risk of congenital anomalies in relation to the uptake of trihalomethane from drinking water during pregnancy/ Grazuleviciene R, Kapustinskiene V, Vencloviene J, Buinauskiene J, Nieuwenhuijsen MJ // Occupational and environmental medicine. London: BMJ Publishing Group. (Original article). ISSN 1351-0711. 2013, vol. 70, no. 4, p. 274-282. Science Citation Index Expanded (Web of Science); MEDLINE; 0.49. Internet access:
8. Association between APOE, SCARB1, PPAR alpha polymorphisms and serum lipids in a population of Lithuanian adults / Smalinskiene A, Petkeviciene J, Luksiene D, Jureniene K, Klumbiene J, Lesauskaite V // Lipids in health and disease. [London]: BioMed Central. ISSN 1476-511X. 2013, vol. 12, p. 1-8. Science Citation Index Expanded (Web of Science); MEDLINE; CABI; CAS; Food Science and Technology Abstracts; Scopus; 0.943.Internet access :

 

Laboratory of Clinical Cardiology

Head of Laboratory
Prof.  Dr. Šarūnas Kinduris
Phone: +370 37 326335
E-mail: sarunas.kinduris@lsmuni.lt

Main activities of laboratory:

1. Evaluation of perioperative period prognostic factors that influence treatment outcome for cardiovascular patients.

2. Selection of treatment strategy in patients with multivessel coronary artery disease after primary percutaneous coronary intervention: importance of follow-up results

3.. Evaluation of significance of myocardial deformation parameters for detection of myocardial fibrosis in valvular heart disease

4. Depression correction relation to heart rate variability parameters (at rest  and at psychological/mathematical stress test) in cardiac surgery patients

5. Experimental study of the effect of ultrasonic (cavitation) energies on function of isolated vascular fragments by using different configurations and power waveguides.

Personnel:

 Jolanta Justina  Vaškelytė,  Head researcher

 Ramūnas Navickas, Head researcher

 Rimantas Benetis Head researcher

 Jonė Venclovienė dr., Senior researcher

 Margarita Beresnevaitė dr., Researcher

 Vytautas Grižas dr., Researcher

 Jūratė Janėnaitė dr., Researcher

 Vida Tumynienė,  Laboratory assistant

 Edmundas Širvinskas, Head researcher

 Judita Andrejaitienė dr. Researcher

 Laima Ralienė dr.,Researcher

 Milda Švagždienė dr., Researcher

 Vincentas Veikutis dr., Head researcher

 Stefanija Bartusevičienė, Senior technician

 Nijolė Augustinavičienė, Laboratory assistant

 Neringa Eimutienė, Laboratory assistant

 Čiuželis Tomas, Senior technician

Projects

1. Improvement of perioperative clinical decisions  for patients with ischemic heart disease and valve pathology. (2011-2013 ).
2. Depression correction relation to heart rate variability parameters (at rest  and at psychological/mathematical stress test) in cardiac surgery patients. (2008-2013).
3. Selection of optimal treatment strategy and prognosis afterprimary percutaneous coronary intervention in patients with ST elevation myocardial infarction and multivessel coronay artery disease. (2010-2013).
4. Experimental study of the effect of ultrasonic (cavitation) energies on function of isolated vascular fragments by using different configurations and power waveguides. (2013-2015).
5. 'Evaluation of perioperative period prognostic factors that influence treatment outcome for cardiovascular patients. (2014 -2018 ). 

Other projects

1. Impact of complete myocardial revascularizationon outcomes of myocardial infarction patients. (2011-2013 ).
2. Evaluation of significance of myocardial deformation parameters for detection of myocardial fibrosis in valvular heart disease (2013-03-01-2015-06-30).
3. Application of cerebrovascular autoregulation monitoring method during cardiac surgery. (2014-04-01 – 2016-12-31).
4. Experimental-clinical study of vascular recanalization and functional repair of cavitation streams generated by ultrasound systems. 2015.07.01 - 2018.03.31.

Main Publications (2018-2013): 

2018  - 2017

1. Alterations of conjunctival glycocalyx and microcirculation in non-septic critically ill patients / Andrius Pranskunas, Tomas Tamosuitis, Neringa Balciuniene, Diana Damanskyte, Edvin Sneider, Astra Vitkauskiene, Edmundas Sirvinskas, Vidas Pilvinis, E. Christiaan Boerma // Microvascular research. San Diego: Elsevier. ISSN 0026-2862. 2018, vol. 118, p. 44-48. Science Citation Index Expanded (Web of Science); MEDLINE; Biological Abstracts; Scopus; 0.192. Internet access:
2. Design and the main parameters of tube-shaped ultrasound wave guide wire / Algimantas Bubulis, Vladimir Minchenia, Vincentas Veikutis, Jonas Navickas, Vytautas Bakanauskas, Paulius Palevičius // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. ISSN 1392-8716. 2017, vol. 19, iss. 2, p. 1383‑1392. Science Citation Index Expanded (Web of Science); Computers & Applied Sciences Complete; INSPEC; Scopus; Academic Search Complete; 0.289.  Internet access:
3. Balance asymmetry properties evaluation for people who are more and less likely to suffer from trauma / Kęstutis Radžiūnas, Margarita Radžiūnienė, Tomas Čiuželis, Alfonsas Vainoras, Jonas Poderys // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. ISSN 1392-8716. 2017, vol. 19, iss. 7, p. 5540-5551.  Science Citation Index Expanded (Web of Science); Scopus; 0.8.  Internet access:
4. Left atrial mechanics in patients with acute STEMI and secondary mitral regurgitation: A prospective pilot CMR feature tracking study / Tomas Lapinskas, Paulius Bučius, Laura Urbonaitė, Agnieta Stabinskaitė, Živilė Valuckienė, Lina Jankauskaitė, Rimantas Benetis, Remigijus Žaliūnas // Medicina. Wrocław: Elsevier. ISSN 1010-660X. 2017, vol. 53, no. 1, p. 11-18. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.217.   Internet access: 
5. Two-dimensional speckle-tracking echocardiography for evaluation of dilative ascending aorta biomechanics / Monika Bieseviciene, Jolanta Justina Vaskelyte, Vaida Mizariene, Rasa Karaliute, Vaiva Lesauskaite, Raimonda Verseckaite // BMC cardiovascular disorders. London: BioMed Central. (Research article). ISSN 1471-2261. 2017, vol. 17, no. 1, p. 1-11. Science Citation Index Expanded (Web of Science); MEDLINE; 0.471.  Internet access :
6. Spectral characteristics of voltage-sensitive indocyanine green fluorescence in the heart / Regina Mačianskienė, Mantė Almanaitytė, Rimantas Treinys, Antanas Navalinskas, Rimantas Benetis, Jonas Jurevičius // Scientific reports. London: Nature Publishing Group. ISSN 2045-2322. 2017, vol. 7, no. 1, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; 1.  Internet access:

2016 

1. Thermography based inflammation monitoring of udder state in dairy cows: sensitivity and diagnostic priorities comparing with routine California mastitis test / Ina Pampariene, Vincentas Veikutis, Vaidas Oberauskas, Judita Zymantiene, Rasa Zelvyte, Arunas Stankevicius, Dalia Marciulionyte, Paulius Palevicius // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. (Oscillations in biomedical engineering). ISSN 1392-8716. 2016, vol. 18, iss. 1, p. 511-521. [Science Citation Index Expanded (Web of Science); COMPENDEX; EBSCO; INSPEC; Scopus; VINITI; 0.25. Internet access:
2. Signal intensity dynamics of malignant lymphoma in diffusion-weighted magnetic resonance imaging compared to positron emission tomography / Rytis Bliūdžius, Laima Dobrovolskienė, Algidas Basevičius, Vincentas Veikutis, Matas Juškevičius, Vaidas Oberauskas // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. ISSN 1392-8716. 2016, vol. 18, iss. 3, p. 1905‑1911. Science Citation Index Expanded (Web of Science); COMPENDEX; EBSCO; INSPEC; Scopus; VINITI; 0.289. Internet access:
3. Comparison of results of endovascular stenting and bypass grafting for TransAtlantic Inter-Society (TASC II) type B, C and D iliac occlusive disease / Rimantas Benetis, Zana Kavaliauskiene, Aleksandras Antusevas, Rytis Stasys Kaupas, Donatas Inciura, Sarunas Kinduris // Archives of medical science : AMS. Poznań: Termedia Publishing House. (Clinical research). ISSN 1734-1922. 2016, vol. 12 no. 2, p. 353-359. Science Citation Index Expanded (Web of Science); CAB Abstracts; Scopus; IndexCopernicus; DOAJ; 0.471.  Internet access:
4. Dobutamine-stress echocardiography speckle tracking imaging in the assessment of hemodynamic significance of coronary artery stenosis in patients with moderate and high probability of coronary artery disease / Eglė Rumbinaitė, Diana Žaliaduonytė-Pekšienė, Mindaugas Vieželis, Indrė Čeponienė, Tomas Lapinskas, Rūta Žvirblytė, Jonė Venclovienė, Kristina Morkūnaitė, Augustinas Bielinis, Rimvydas Šlapikas, Jolanta Justina Vaškelytė // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2016, vol. 52, no. 6, p. 331-339. [Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.386.  Internet access:
5. Tracking restoration of park and urban street settings in coronary artery disease patients / Regina Grazuleviciene, Jone Vencloviene, Raimondas Kubilius, Vytautas Grizas, Asta Danileviciute, Audrius Dedele, Sandra Andrusaityte, Astra Vitkauskiene, Rasa Steponaviciute, Mark J. Nieuwenhuijsen // International journal of environmental research and public health. Basel: MDPI. ISSN 1660-4601. 2016, vol. 13, no. 6, p. 1-9. [Science Citation Index Expanded (Web of Science); MEDLINE; 0.2.  Internet access:
6. Investigation of vitamin D-binding protein polymorphism impact on coronary artery disease and relationship with longevity: own data and a review / Donatas Stakisaitis, Vita Lesauskaitė, Milda Girdauskaitė, Ernestas Janulionis, Albertas Ulys, Rimantas Benetis // International journal of endocrinology. Cairo: Hindawi Publishing Corporation. (Research article). ISSN 1687-8337. 2016, vol. 2016, p. 1-7. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; 0.333. Internet access : 
7. Successfully treated severe obstetric sepsis and acute respiratory distress syndrome with extracorporeal membrane oxygenation / Rimantas Benetis, Ruta Nadisauskiene, Edmundas Sirvinskas, Tadas Lenkutis, Adakrius Siudikas, Vytaute Kadusauskaitė, Dalia Railaitė, Arturas Sukovas, Vytautas Abraitis // Perfusion. London: SAGE Publications. (Case report). ISSN 0267-6591. 2016, vol. 31, no. 4, p. 343-346. Science Citation Index Expanded (Web of Science); MEDLINE; Academic Search Premier; Biological Abstracts; Biological Abstracts Family of Products; BIOSIS database; BIOSIS Previews; Cumulative Index to Nursing and Allied Health Literature CINAHL; Health Economics Evaluations Database (HEED); ISI Discovery Agent; Scopus; 0.314. Internet access: 
8. Impact of a cognitive behavioral intervention on health-related quality of life and general heart rate variability in patients following cardiac surgery: an effectiveness study / Margarita Beresnevaitė, Rimantas Benetis, Graeme J. Taylor, Svetlana Rašinskienė, Albinas Stankus, Sarunas Kinduris // Psychosomatics. Oxford, UK: Elsevier. (Original research reports). ISSN 0033-3182. 2016, vol. 57, no. 6, p. 605-615. Science Citation Index Expanded (Web of Science); MEDLINE; PsycINFO; EMBASE; Scopus; 1.118.  Internet access: 
9. Voltage-sensitive fluorescence of indocyanine green in the heart / Irma Martišienė, Regina Mačianskienė, Rimantas Treinys, Antanas Navalinskas, Mantė Almanaitytė, Dainius Karčiauskas, Audrius Kučinskas, Ramunė Grigalevičiūtė, Vilma Zigmantaitė, Rimantas Benetis, Jonas Jurevičius // Biophysical journal. Cambridge, MA: Cell Press. ISSN 0006-3495. 2016, vol. 110, no. 3, p. 723-732. Science Citation Index Expanded (Web of Science); MEDLINE; 1.102. Internet access:
   
10. Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels / Kestutis Maciunas, Mindaugas Snipas, Nerijus Paulauskas, Feliksas F. Bukauskas // Journal of general physiology. New York: Rockefeller University Press. (Research article). ISSN 0022-1295. 2016, vol. 147, iss. 3, p. 273-288. Science Citation Index Expanded (Web of Science); MEDLINE; BIOSIS Previews; 1.5.  Internet access:
11. Stochastic model of gap junctions exhibiting rectification and multiple closed states of slow gates / Mindaugas Snipas, Tadas Kraujalis, Nerijus Paulauskas, Kestutis Maciunas, Feliksas F. Bukauskas // Biophysical journal. Cambridge, MA: Cell Press. ISSN 0006-3495. 2016, vol. 110, no. 6, p. 1322-1333. Science Citation Index Expanded (Web of Science); MEDLINE; 2.  Internet access:
12. FGF-1 triggers pannexin-1 hemichannel opening in spinal astrocytes of rodents and promotes inflammatory responses in acute spinal cord slices / Juan Mauricio Garré, Guang Yang, Feliksas F. Bukauskas, Michael V. L. Bennett // Journal of neuroscience. Washington, DC: Society for Neuroscience. ISSN 0270-6474. 2016, vol. 36, no. 17, p. 4785-4801. Science Citation Index Expanded (Web of Science); MEDLINE; 0.559.  Internet access:
13. Early and late diastolic strain rate vs global longitudinal strain at rest and during dobutamine stress for the assessment of significant coronary artery stenosis in patients with a moderate and high probability of coronary artery disease / Egle Rumbinaite, Diana Zaliaduonyte-Peksiene, Tomas Lapinskas, Ruta Zvirblyte, Arnas Karuzas, Ieva Jonauskiene, Mindaugas Viezelis, Indre Ceponiene, Olivija Gustiene, Rimvydas Slapikas, Jolanta Justina Vaskelyte // Echocardiography. Hoboken: Wiley. (Original investigation). ISSN 0742-2822. 2016, vol. 33, no. 10, p. 1512-1522. Science Citation Index Expanded (Web of Science); MEDLINE; 0.091.  Internet access :

2015 

1. Artifacts in computer tomography imaging: how it can really affect diagnostic image quality and confuse clinical diagnosis? / Vincentas Veikutis, Tomas Budrys, Algidas Basevicius, Saulius Lukosevicius, Rymante Gleizniene, Ramunas Unikas, Darijus Skaudickas // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. (Oscillations in biomedical engineering). ISSN 1392-8716. 2015, vol. 17, iss. 2, p. 995‑1003.Science Citation Index Expanded (Web of Science); COMPENDEX; INSPEC; Scopus; VINITI; 0.247. Internet access:
2. IVUS-VH relation to the extent and composition of atherosclerotic plaque and clinical outcome prognosis / Kristina Morkunaite, Ramunas Unikas, Gediminas Jarusevicius, Gintare Sakalyte, Vincentas Veikutis, Mindaugas Viezelis, Algimantas Bubulis // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. (Oscillations in biomedical engineering). ISSN 1392-8716. 2015, vol. 17, iss. 6, p. 3279-3285. Science Citation Index Expanded (Web of Science); COMPENDEX; INSPEC; Scopus; VINITI; 0.247. Internet access:
3. Impact of hypertension on postreperfusion left ventricular recovery in patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease / Edvardas Vaicekavičius, Donatas Vasiliauskas, Ramūnas Navickas, Irena Milvidaitė, Ramūnas Unikas, Jonė Venclovienė, Raimondas Kubilius // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2015, vol. 51, no. 1, p. 38-45. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.808. Internet access:
4. Correlation of magnesium deficiency with C-reactive protein in elective cardiac surgery with cardiopulmonary bypass for ischemic heart disease / Milda Švagždienė, Edmundas Širvinskas, Dalė Baranauskienė, Dalia Adukauskienė // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2015, vol. 51, no. 2, p. 100-106. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.866.  Internet access:
5. Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction / Edita Jankauskienė, Paulius Orda, Eglė Rumbinaitė, Diana Žaliaduonytė-Pekšienė, Rasa Steponavičiutė, Aurelija Krasauskienė, Jolanta Justina Vaškelytė, Robertas Bunevičius // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2015, vol. 51, no. 4, p. 209-216. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.354. Internet access:
6. Impact of left ventricular function on health-related quality of life in coronary artery disease patients / Margarita Staniūtė, Jolanta Vaškelytė, Eglė Rumbinaitė, Birutė Kaminskaitė, Sigita Samsanavičienė, Sigita Plungienė, Julija Brožaitienė, Robertas Bunevičius // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2015, vol. 51, no. 4, p. 233-239. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.53.Internet access :
7. Does treatment impact health outcomes for patients after acute coronary syndrome? / Jelena Umbrasienė, Giedrius Vanagas, Jon Venclovienė // International journal of environmental research and public health. Basel: MDPI. ISSN 1660-4601. 2015, vol. 12, no. 6, p. 6136-6147. Science Citation Index Expanded (Web of Science); MEDLINE; EMBASE; Scopus; Global Health (CABI); 0.471. Internet access:
8. Exogenous connexin43-expressing autologous skeletal myoblasts ameliorate mechanical function and electrical activity of the rabbit heart after experimental infarction / Antanavičiūtė I, Ereminienė E, Vysockas V, Račkauskas M, Skipskis V, Rysevaitė K, Treinys R, Benetis R, Jurevičius J, Skeberdis VA // International journal of experimental pathology. Oxford, OX: Blackwell Scientific Publications. (Original article). ISSN 0959-9673. 2015, vol. 96, no. 1, p. 42-53. Science Citation Index Expanded (Web of Science); MEDLINE; Index Veterinarius; CAB Abstracts® (CABI); 1.342. Internet access :
9. FBN1 polymorphisms in patients with the dilatative pathology of the ascending thoracic aorta / Lesauskaite V, Sepetiene R, Jariene G, Patamsyte V, Zukovas G, Grabauskyte I, Stanioniene Z, Sirmenis R, Benetis R // European journal of cardio-thoracic surgery. Kidlington, Oxford, UK: Elsevier Science. ISSN 1010-7940. 2015, vol. 47, no. 4, p. e124-e130. Science Citation Index Expanded (Web of Science); MEDLINE; 1.556. Internet access:
10. Effects of sevoflurane vs. propofol on mitochondrial functional activity after ischemia-reperfusion injury and the influence on clinical parameters in patients undergoing CABG surgery with cardiopulmonary bypass / Sirvinskas E, Kinderyte A, Trumbeckaite S, Lenkutis T, Raliene L, Giedraitis S, Macas A, Borutaite V // Perfusion. London: SAGE Publications. (Original paper). ISSN 0267-6591. 2015, vol. 30, no. 7, p. 590-595. Science Citation Index Expanded (Web of Science); MEDLINE; Academic Search Premier; Biological Abstracts; Biological Abstracts Family of Products; BIOSIS Previews; HEED: Health Economic Evaluations Database; Scopus; 0.433. Internet access :
11. Evolution of action potential alternans in rabbit heart during acute regional ischemia / Martišienė I, Jurevičius J, Vosyliūtė R, Navalinskas A, Treinys R, Mačianskienė R, Benetis R, Matiukas A, Pertsov AM // BioMed research international. New York: Hindawi Publishing Corporation. (Research article). ISSN 2314-6133. 2015, vol. 2015, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1.1. Internet access:
    
12. Evaluation of excitation propagation in the rabbit heart: optical mapping and transmural microelectrode recordings / Regina Mačianskienė, Irma Martišienė, Antanas Navalinskas, Rūta Vosyliūtė, Rimantas Treinys, Birutė Vaidelytė, Rimantas Benetis, Jonas Jurevičius // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2015, vol. 10, no. 4, p. 1-18. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Chemical Abstracts Service (CAS); AGRICOLA; PyscINFO; Zoological Records; DOAJ; 0.875. Internet access:
13. Blood plasma TGF- β1 concentration in sporadic dilatative pathology of ascending aorta: more questions than answers / Sepetiene R, Patamsyte V, Zukovas G, Jariene G, Stanioniene Z, Benetis R, Lesauskaite V // PloS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2015, vol. 10, no. 6, p. 1-7.Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; Chemical Abstracts Service (CAS); AGRICOLA; PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; 1.485. Internet access:
14. The Effect of park and urban environments on coronary artery disease patients: A randomized trial / Grazuleviciene R, Vencloviene J, Kubilius R, Grizas V, Dedele A, Grazulevicius T, Ceponiene I, Tamuleviciute-Prasciene E, Nieuwenhuijsen MJ, Jones M, Gidlow C // BioMed research international. New York: Hindawi Publishing Corporation. (Clinical study). ISSN 2314-6133. 2015, vol. 2015, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.203. Internet access:
15.  Association between fibrillin1 polymorphisms (rs2118181, rs10519177) and transforming growth factor β1 concentration in human plasma / Ramune Sepetiene, Vaiva Patamsyte, Giedrius Zukovas, Giedre Jariene, Zita Stanioniene, Rimantas Benetis, Abdonas Tamosiunas, Vaiva Lesauskaite // Molecular medicine. Manhasset, NY: Feinstein Institute for Medical Research. ISSN 1076-1551. 2015, vol. 21, p. 735-738. Science Citation Index Expanded (Web of Science); MEDLINE; 1.516. Internet access:

2014 

1.  Association between obesity and high blood pressure among Lithuanian adolescents: a cross-sectional study/ Dulskiene V, Kuciene R, Medzioniene J, Benetis R // Italian journal of pediatrics. London: BioMed Central. ISSN 1720-8424. 2014, vol. 40, no. 1, p. 1-18. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; IndexCopernicus; 1. Internet access :
2. Evaluation of complexity of induced necrosis zone shape by means of principal component analysis / Darijus Skaudickas, Vincentas Veikutis, Aleksandras Vitkus, Greta Peciulytė, Dalia Marciulionyte, Gintare Sakalyte, Algimantas Krisciukaitis, Gintautas Vaitiekaitis // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. ISSN 1392-8716. 2014, vol. 16, iss. 8, p. 4115-4124. Science Citation Index Expanded (Web of Science); COMPENDEX; EBSCO; INSPEC; Scopus; VINITI; 0.25.Internet access :
3. The Effect of CYP2C9, VKORC1 and CYP4F2 polymorphism and of clinical factors on warfarin dosage during initiation and long-term treatment after heart valve surgery / Tatarunas V, Lesauskaite V, Veikutiene A, Grybauskas P, Jakuska P, Jankauskiene L, Bartuseviciute R, Benetis R // Journal of thrombosis and thrombolysis. [Dordrecht ; Norwell, MA]: Kluwer Academic Publishers. ISSN 0929-5305. 2014, vol. 37, no. 2, p. 177-185. Science Citation Index Expanded (Web of Science); MEDLINE; 0.707. Internet access:
4. Factors affecting primary patency of stenting for TransAtlantic Inter-Society (TASC II) type B, C, and D iliac occlusive disease / Žana Kavaliauskienė, Rimantas Benetis, Donatas Inčiūra, Nerijus Aleksynas, Rytis Stasys Kaupas, Aleksandras Antuševas // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2014, vol. 50, no. 5, p. 287-294. Prieiga per internetą: <http://www.ncbi.nlm.nih.gov/pubmed/25488165>. [Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.236. Internet access: 
5. Evaluation of left ventricular longitudinal function and synchrony after dual chamber pacemaker implantation / Kristina Baronaitė-Dūdonienė, Jolanta Vaškelytė, Aras Puodžiukynas, Vytautas Zabiela, Tomas Kazakevičius, Gintarė Šakalytė // Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2014, vol. 50, no. 6, p. 340-344. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.236.  Internet access:
6. Effectiveness of a new exercise program after lower limb arterial blood flow surgery in patients with peripheral arterial disease: a randomized clinical trial / Jakubsevičienė E, Vasiliauskas D, Velička L, Kubilius R, Milinavičienė E, Venclovienė J // International journal of environmental research and public health. Basel: MDPI. ISSN 1660-4601. 2014, vol. 11, no. 8, p. 7961-7976. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; Scopus; CAB Abstracts (CABI); Food Science and Technology Abstracts (IFIS); 1.118. Internet access: 
7. Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene / Zaliaduonyte-Peksiene D, Simonyte S, Lesauskaite V, Vaskelyte J, Gustiene O, Mizariene V, Jurkevicius R, Jariene G, Tamosiunas A, Zaliunas R // Journal of the renin-angiotensin-aldosterone system : JRAAS. London: SAGE Publications. ISSN 1470-3203. 2014, vol. 15, no. 3, p. 286-293. Science Citation Index Expanded (Web of Science); MEDLINE; 0.866. Internet access:
   
8. Effects of intraoperative external head cooling on short-term cognitive function in patients after coronary artery bypass graft surgery / Sirvinskas E, Usas E, Mankute A, Raliene L, Jakuska P, Lenkutis T, Benetis R // Perfusion. London: SAGE Publications. (Original paper). ISSN 0267-6591. 2014, vol. 29, no. 2, p. 124-129. Prieiga per internetą: <http://www.ncbi.nlm.nih.gov/pubmed/23878011>. [Science Citation Index Expanded (Web of Science); MEDLINE; Academic Search Premier; Biological Abstracts; Biological Abstracts Family of Products; BIOSIS Previews; Health Economics Evaluations Database (HEED); Scopus; 0.958. Internet access:
9. Distribution of adrenergic and cholinergic nerve fibres within intrinsic nerves at the level of the human heart hilum / Petraitiene V, Pauza DH, Benetis R // European journal of cardio-thoracic surgery. Kidlington, Oxford, UK: Elsevier Science. (Original article). ISSN 1010-7940. 2014, vol. 45, no. 6, p. 1097-1105. Science Citation Index Expanded (Web of Science); MEDLINE; 0.471. Internet access:
10. Microcirculatory, mitochondrial, and histological changes following cerebral ischemia in swine / Suchadolskiene O, Pranskunas A, Baliutyte G, Veikutis V, Dambrauskas Z, Vaitkaitis D, Borutaite V // BMC neuroscience. London: BioMed Central. (Research article). ISSN 1471-2202. 2014, vol. 15, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; 0.286. Internet access:
11. The Relationship of green space, depressive symptoms and perceived general health in urban population / Reklaitiene R, Grazuleviciene R, Dedele A, Virviciute D, Vensloviene J, Tamosiunas A, Baceviciene M, Luksiene D, Sapranaviciute-Zabazlajeva L, Radisauskas R, Bernotiene G, Bobak M, Nieuwenhuijsen MJ // Scandinavian journal of public health. London: Sage Publications. ISSN 1403-4948. 2014, vol. 42, no. 7, p. 669-676. Science Citation Index Expanded (Web of Science); MEDLINE; 1.507. Internet access:
12. The Effect of solar-geomagnetic activity during and after admission on survival in patients with acute coronary syndromes / Vencloviene J, Babarskiene R, Milvidaite I, Kubilius R, Stasionyte J // International journal of biometeorology. New York: Springer. ISSN 0020-7128. 2014, vol. 58, no. 6, p. 1295-1303. Prieiga per internetą: <http://www.ncbi.nlm.nih.gov/pubmed/24018849>. [Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Astrophysics Data System (ADS); EBSCO; CSA; ProQuest; CAB International; Abstracts in Anthropology; AGRICOLA; ASFA; BIOSIS; Gale; Global Health; IndexCopernicus; VINITI; 0.693. Internet access :

2013 

1. New mathematical model for examination of cervical cancer by using diffusion–weighted magnetic resonance imaging / Vaida Atstupenaite, Algidas Basevicius, Saulius Lukosevicius, Vincentas Veikutis, Daiva Vaitkiene, Arturas Inciura, Vidmantas Januskevicius, Dinas Vaitkaitis // Journal of vibroengineering. Vilnius: Vibromechanika. ISSN 1392-8716. 2013, vol. 15, iss. 2, p. 675-683. [Science Citation Index Expanded (Web of Science); Academic Search Complete; Central & Eastern European Academic Source; Computers & Applied Sciences Complete; Current Abstracts; INSPEC; Scopus; TOC Premier; VINITI; 0.217. Internet access:
2. Surgical treatment of ventricular septal defect following myocardial infarction: a case report / Eglė Ereminienė, Rūta Jurgaitienė, Rimantas Benetis, Giedrė Bakšytė, Giedrė Stanaitienė // Medicina. Kaunas: Lietuvos sveikatos mokslų universitetas. (Continuing medical education). ISSN 1010-660X. 2013, t. 49, Nr. 4$$2013/49:4/200, p. 200-205. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.2.  Internet access:
3. Prognosis of in-hospital myocardial infarction course for diabetic and nondiabetic patients using a noninvasive evaluation of hemodynamics and heart rate variability / Rūta Ablonskytė-Dūdonienė, Giedrė Bakšytė, Indrė Čeponienė, Algimantas Kriščiukaitis, Kęstutis Drėgūnas, Eglė Ereminienė // Medicina. Kaunas: Lietuvos sveikatos mokslų universitetas. (Clinical investigations). ISSN 1010-660X. 2013, t. 49, Nr. 6, p. 262-272. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.236.  Internet access: 
4. Outcome of the first successful heart-lung transplantation in the Baltic Countries / Raimondas Kubilius, Kęstutis Malakauskas, Loreta Jankauskienė, Povilas Jakuška, Ramūnas Bolys, Evelina Pociūtė, Vaidotas Boguševičius, Rimantas Benetis // Medicina. Kaunas: Lietuvos sveikatos mokslų universitetas. (Continuing medical education). ISSN 1010-660X. 2013, t. 49, Nr. 12, p. 535-537. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.177.  Internet access:
   
5. A case-control study of readmission to the intensive care unit after cardiac surgery / Benetis R, Sirvinskas E, Kumpaitiene B, Kinduris S // Medical science monitor. Warsaw: Medical Science International Publishing. (Clinical research). ISSN 1643-3750. 2013, vol. 19, p. 148-152.Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; 1.061.  Internet access:
   
6. The Effect of solar–geomagnetic activity during hospital admission on coronary events within 1 year in patients with acute coronary syndromes / J. Vencloviene, R. Babarskiene, I. Milvidaite, R. Kubilius, J. Stasionyte // Advances in space research. Oxford ; New York: Committee by Pergamon Press. ISSN 0273-1177. 2013, vol. 52, no. 12, p. 2192-2198. Science Citation Index Expanded (Web of Science); Chemical Abstracts; Geographical Abstracts; Geological Abstracts; Scopus; 0.693.   Internet access:
7. The Factors associated with improving of quality of life in psychological rehabilitation and usual care groups of patients after cardiac surgery / Beresnevaite M, Benetis R, Rasinskiene S, Kinduris S // Proceedings of EAPM 2014 Care and Cure an Integrated Approach to Psychosomatic Medicine. Annual Meeting of the European Association of Psychosomatic Medicine : Sibiu, Romania, 25-28 June 2014 / Editors: Dan L. Dumitrascu, Wolfgang Soellner. Bologna: MEDIMOND, 2014, ISBN 9788875877019. p. 17-21 : lent. [Conference Proceedings Citation Index; 0.75.  Internet access:

 

Gediminas Jaruševičius,

Head of laboratory, Head researcher   
Tel.( 8 37) 326094, 
E-mail: gediminas.jarusevicius@lsmuni.lt

Personnel:

 Alfonsas Vainoras,  Head researcher

 Vidmantas Jurkonis dr. Senior researcher

 Vytautas Zabiela dr., Researcher

 Rimtautas Ruseckas, Senior engineer programmer

 Rūta Jurkonienė,  Senior engineer programmer

 Vytenis Miškinis,  Senior engineer programmer

 Nijolė Rakauskienė, Laboratory assistant

 

Main directions of research:

1. Development methods and systems for analysis of cardiac signals at rest, during physical load and long term monitoring

2. Evaluation of human functional state by using non linear analysis and complex systems methods.

 3. Assessment the complexity of heart processes on aim to observe the dynamics of cardiovascular system during invasive procedures.

 

Projects:

Projects performed

purpose to assess the dynamics of cardiovascular system (2009-14).

  Project refused   

  Proposal  for  Horizon 2020 “Impact of the local and global geomagnetic field on cardiovascular system health” [GEOHEALTH] (refused in 2015)

 

Main publications ( 2018-2013):

 

2018 – 2017 

1. ALong-term study of heart rate variability responses to changes in the solar and geomagnetic environment / Abdullah Alabdulgader, Rollin McCraty, Michael Atkinson, York Dobyns, Alfonsas Vainoras, Minvydas Ragulskis, Viktor Stolc // Scientific reports. London: Nature Publishing Group. ISSN 2045-2322. 2018, vol. 8, no. 1, p. 1-14. [Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; 0.319. Internet access:
2. Correlation between changes in local earth’s magnetic field and cases of acute myocardial infarction / Gediminas Jaruševičius, Tautvydas Rugelis, Rollin McCraty, Mantas Landauskas, Kristina Berškienė, Alfonsas Vainoras // International journal of environmental research and public health. Basel: MDPI. ISSN 1660-4601. 2018, vol. 15, no. 3, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 0.882. Internet access:
3. Balance asymmetry properties evaluation for people who are more and less likely to suffer from trauma / Kęstutis Radžiūnas, Margarita Radžiūnienė, Tomas Čiuželis, Alfonsas Vainoras, Jonas Poderys // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. ISSN 1392-8716. 2017, vol. 19, iss. 7, p. 5540-5551.  Science Citation Index Expanded (Web of Science); Scopus; 0.8. Internet access:
4. Evaluation of atrial fibrillation management and cardiovascular risk profile in atrial fibrillation patients: A cross-sectional survey / Gediminas Račkauskas, Vytautas Zabiela, Germanas Marinskis, Arvydas Baranauskas, Deimilė Balkutė, Justina Alunderytė, Aras Puodžiūkynas, Tomas Kazakevičius, Vilius Kviesulaitis, Audrius Aidietis // Medicina. Wrocław: Elsevier. (Guidelines). ISSN 1010-660X. 2017, vol. 53, no. 1, p. 19-25. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.141.Internet access:
5. Synchronization of Human Autonomic Nervous System Rhythms with Geomagnetic Activity in Human Subjects / Rollin McCraty, Mike Atkinson, Viktor Stolc, Abdullah A. Alabdulgader, Alfonsas Vainoras, Minvydas Ragulskis // International journal of environmental research and public health. Basel: MDPI. ISSN 1660-4601. 2017, vol. 14, no. 7, p. 1-18. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 0.373. Internet access: 
6. Identification of a Group's Physiological Synchronization with Earth's Magnetic Field / Inga Timofejeva, Rollin McCraty, Mike Atkinson, Roza Joffe, Alfonsas Vainoras, Abdullah A. Alabdulgader, Minvydas Ragulskis // International journal of environmental research and public health. Basel: MDPI. ISSN 1660-4601. 2017, vol. 14, no. 9, p. 1-22. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 0.319. Internet access:
7. Heart rate variability after radiofrequency ablation of epicardial ganglionated plexuses on the ovine left atrium / Vilius Kviesulaitis, Aras Puodziukynas, Dainius Haroldas Pauza, Vytautas Zabiela, Tomas Kazakevicius, Raimundas Vaitkevicius, Evaldas Diržinauskas, Vytenis Semaška, Antanas Strazdas, Ruta Unikaite, Kristina Rysevaite, Neringa Pauziene, Remigijus Zaliunas // BMC cardiovascular disorders. London: BioMed Central. (Research article; Non-coronary artery cardiac disease). ISSN 1471-2261. 2017, vol. 17, no. 1, p. 1-8.Science Citation Index Expanded (Web of Science); MEDLINE; 0.133. Internet access:
8. New approach for visualization of relationships between RR and JT intervals / Pranas Ziaukas, Abdullah Alabdulgader, Alfonsas Vainoras, Zenonas Navickas, Minvydas Ragulskis // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2017, vol. 12, no. 4, p. 1-18. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; AGRICOLA; 0.346. Internet access: 

  2016 – 2013

1. Method for prediction of acute hypotensive episodes / Vytautas Petkus, Alfonsas Vainoras, Kristina Berskiene, Zenonas Navickas, Rimtautas Ruseckas, Ian Piper, Mantas Deimantavicius, Arminas Ragauskas // Elektronika ir elektrotechnika = Electronics and electrical engineering. Kaunas: Technologija. ISSN 1392-1215. 2016, vol. 22, no. 1, p. 44-48. Science Citation Index Expanded (Web of Science); 0.28. Internet access: 
2. Hypotension investigation, prospective clinical study / Ian Piper, Alfonsas Vainoras, Kristina Berskiene, Rimtautas Ruseckas, Vidmantas Jurkonis, Liepa Bikulciene, Zenonas Navickas, Dovilė Karaliene, Arminas Ragauskas, Mantas Deimantavicius // Elektronika ir elektrotechnika = Electronics and electrical engineering. Kaunas: Technologija. ISSN 1392-1215. 2016, vol. 22, no. 2, p. 33-37. [Science Citation Index Expanded (Web of Science); 0.49.  Internet access:
3. Human heart rhythm sensitivity to earth local magnetic field fluctuations / Abdullah Alabdulgade, Rollin Maccraty, Mike Atkinson, Alfonsas Vainoras, Kristina Berškienė, Vilma Mauricienė, Algė Daunoravičienė, Zenonas Navickas, Rasa Šmidtaitė, Mantas Landauskas // Journal of vibroengineering : JVE. Kaunas: JVE International Ltd. (Oscillations in biomedical engineering). ISSN 1392-8716. 2015, vol. 17, iss. 6, p. 3271‑3278. Science Citation Index Expanded (Web of Science); COMPENDEX; EBSCO; INSPEC; Scopus; VINITI; 0.245.  Internet access: 
4.  A modified Lewis ECG lead system for ambulatory monitoring of atrial arrhythmias / Petrėnas A, Marozas V, Jaruševičius G, Sörnmo L // Journal of electrocardiology. New York, NY: Churchill Livingstone. ISSN 0022-0736. 2015, vol. 48, no. 2, p. 157-163.Science Citation Index Expanded (Web of Science); MEDLINE; 0.433. Internet access:
5. Heart rhythm fluctuation in peloidotherapy / Giedrė Taletavičienė, Kęstutis Ramanauskas, Gediminas Jaruševičius, Alfonsas Vainoras // Journal of vibroengineering. Vilnius: Vibromechanika. ISSN 1392-8716. 2013, vol. 15, iss. 1, p. 428-437. [Science Citation Index Expanded (Web of Science); Academic Search Complete; Central & Eastern European Academic Source; Computers & Applied Sciences Complete; Current Abstracts; INSPEC; Scopus; TOC Premier; VINITI; 0.433. Internet access:
   
6. The Measure of Human Vital Signals Complexity by Matrix Analysis / Liepa Bikulčienė, Eurelija Venskaitytė, Liudas Gargasas, and Vidmantas Jurkonis // Chaos and Complex Systems : Proceedings of the 4th International Interdisciplinary Chaos Symposium / Editors: Stavros G. Stavrinides, Santo Banerjee, Suleyman Hikmet Caglar, Mehmet Ozer. Berlin Heidelberg: Springer-Verlag, 2013, ISBN 978-3-642-33913-4. p. 449-458. [Conference Proceedings Citation Index; Springer LINK.; 0.75.Internet access :

Head of the Laboratory
Prof. Edgaras Stankevičius
Tel. +370 327257, +370 687 4898
Email: edgaras.stankevicius@lsmuni.lt

Main activities of the laboratory:

1. Cardiovascular functions research
2. Collaborative research on medicinal products and medicine application models with all other clinical departments

Personnel:

Prof. Edgaras Stankevičius
Senior Researcher (edgaras.stankevicius@lsmuni.lt)

dr. Aiste Jekabsone
Senior Researcher (aiste.jekabsone@lsmuni.lt)

Justina Rusteikaitė
Junior Researcher, Doctorate Student (justina.rusteikaite@lsmu.lt)

Agilė Tunaitytė 
Laboratory Assistant, Secretary (agile.tunaityte@lsmu.lt +37068982592)

Augusta Volkevičiūtė
Laboratory Assistant (augusta.volkeviciute@lsmu.lt +37063071046)

Current orders:

1. CONTRACT FOR RESEARCH AND EXPERIMENTAL DEVELOPMENT SERVICES, UAB Animagena;
2. CONTRACT FOR RESEARCH AND EXPERIMENTAL DEVELOPMENT SERVICES, UAB Teltonic Telemedics;
3. Preparation of a set of health assessment criteria for the implementation of a methodology for the treatment of chronic diseases for the personalised treatment of multimorbidity in Lithuania, UAB Signata.

Main publications:

1. Abramavičius, S., Volkevičiūtė, A., Tunaitytė, A., Venslauskas, M., Bubulis, A., Bajoriūnas, V., Stankevičius, E. Low-frequency (20 kHz) ultrasonic modulation of drug action // Ultrasound in Medicine & Biology. New York : Elsevier. ISSN 0301-5629. eISSN 1879-291X. 2020, Vol. 00, p. 1-15. DOI: 10.1016/j.ultrasmedbio.2020.07.002.
2. Abramavičius S, Venslauskas M, Vaitkus A, Gudžiūnas V, Laucius O, Stankevičius E. Local Vibrational Therapy for Essential Tremor Reduction: A Clinical Study. Medicina (Kaunas). 2020 Oct 21;56(10):552. doi: 10.3390/medicina56100552. PMID: 33096872; PMCID: PMC7589646.
3. Radzevičienė, A., Marquet, P., Maslauskienė, R., Vaičiūnienė, R., Kaduševičius, E., & Stankevičius, E. (2020). Analyses of AUC(0-12) and C0 Compliances within Therapeutic Ranges in Kidney Recipients Receiving Cyclosporine or Tacrolimus. Journal of clinical medicine, 9(12), 3903. https://doi.org/10.3390/jcm9123903.
4. Abramavicius S, Galaune V, Tunaityte A, Vitkauskiene A, Gumbrevicius G, Radzeviciene A, Maciulaitis R. The Glomerular Filtration Rate Estimators in the Pharmacokinetic Modelling in Acute Kidney Injury: An Observational Study. Antibiotics. 2021; 10(2):158. https://doi.org/10.3390/antibiotics10020158.
5. Zvikas V, Urbanaviciute I, Bernotiene R, Kulakauskiene D, Morkunaite U, Balion Z, Majiene D, Liaudanskas M, Viskelis P, Jekabsone A, Jakstas V. Investigation of Phenolic Composition and Anticancer Properties of Ethanolic Extracts of Japanese Quince Leaves. Foods. 2021; 10(1):18. https://doi.org/10.3390/foods10010018
6. Balion Z, Ramanauskienė K, Jekabsone A, Majienė D. The Role of Mitochondria in Brain Cell Protection from Ischaemia by Differently Prepared Propolis Extracts. Antioxidants. 2020; 9(12):1262. https://doi.org/10.3390/antiox9121262

Registered patents:

In the field of development of medical devices for the treatment of peripheral arterial occlusion and myocardial infarction - the laboratory staff has registered two patents: LT 6527 B and LT 6684 B

Planned projects:

1. Exosome research and biotechnological functionalisation for neuroregeneration, NeuroFocus
2. Non-invasive devices and methods for the treatment of pulmonary hypertension and acute respiratory distress syndrome
3. An Innovative, Personalised, ICD-Based Model for Investigation of Blood-Brain Barrier Damage Caused by Viral Inflammation
4. Development of in vitro models for preclinical studies of COVID-19 infection and medicines
5. Remote monitoring module for monitoring the vital signs of patients with communicable diseases and multimorbidity

 

Laboratory of Cell Culture

Vytenis Arvydas Skeberdis, 

Head of laboratory, Head researcher,  tel.: 302880,

e-mail: arvydas.skeberdis@lsmuni.lt

Personnel:

 Ieva Antanavičiūtė dr.,Senior researcher

 Velasco Sergio Bordel dr., Senior researcher

 Renata Sveikatienė, Junior researcher

Vaidas Jotautis, Junior researcher

 Vytautas Raškevičius, Junior researcher

 Gintarė Milašiūtė,  Laboratory assistant

 

THE MAIN RESEARCH ACTIVITIES OF THE LABORATORY

• Intracellular and intercellular signaling in cardiac myocytes and cell cultures
• Stem cell therapy for heart repair

Laboratory of Molecular Cardiology

Contacts
Website

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Projects                                                                  Publications                                             Research group

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Head of the Laboratory

Prof. habil. dr. Vaiva Lesauskaitė
Phone: +370 37 302874
E-mail: vaiva.lesauskaite@lsmuni.lt

 

The laboratory was established in 2008. Prof. habil. dr. Vaiva Lesauskaitė was elected as the head of the laboratory.

 

Research topics:

1. Cardiovascular diseases genetic epidemiology.

2. Candidate genes and their variants relevant to cardiovascular morphogenesis researches.

3. Cardiovascular diseases pharmacogenetic researches.

The laboratory is involved in the clinical and research collaboration with LUHS Cardiothoracic and Vascular Surgery, Cardiology and other institutions.

 

Laboratory of Molecular Cardiology operating principles:

• Research must be carried on time, high-quality and in compliance with the highest EU standards.
• Laboratory workers constantly renew their knowledge of raising qualification.
• Results of scientific research results should be published in Lithuanian and international scientific journals also presented at conferences.
• Laboratory workers must carry out academic activities, sharing of experience and knowledge.

Quality Policy:

• Mission – increase the diagnostic molecular genetics research availability for Lithuanian residents.
• Vision – health care quality improvement. Physicians using diagnostic molecular genetics research results more accurately diagnose diseases and will better predict their process and choose the most appropriate treatment strategy.
• Strategy – execution of laboratory activities are integrating clinical diagnostic and research laboratory quality system into the management system and operation of accreditation, according to standard. BS EN ISO / IEC 17025 standard.

 

Personnel:

Vaiva Lesauskaitė habil. dr. , chief researcher / head of the laboratory

Giedrė Jarienė dr. , researcher

Alina Smalinskienė dr. , researcher

Sandrita Šimonytė dr. , researcher

Ramunė Šepetienė dr. , junior researcher

Vacis Tatarūnas dr. , senior researcher

Audronė Veikutienė dr. , researcher

Vilius Skipskis dr. , researcher

Vaiva Patamsytė, junior researcher

Lukas Gudaitis, junior researcher

Ona Rūta Šereivienė, senior laboratory assistant

Dovydas Gečys, laboratory assistant

Edita Kuncevičienė, laboratory assistant

Ieva Eitminavičiūtė, laboratory assistant

 

 

Projects:

 

1. Project title: National research programme “Chronic non-communicable diseases”: Pathology of ascending aorta: search for molecular and biomechanical markers of dilatation

Summary: Dilatative pathology of ascending aorta (DPAA) is a well-known life-threatening condition for aortic dissection.

DPAA usually develops without any symptoms before clinically manifested sudden aortic wall dissection. One of the most feasible methods for the diagnosis of aortic dilation is 2D echocardiography, however it is not relevant for prediction of dilation rate and prevention of complications. Therefore, noninvasive predictors of aortic dilation are required and the aim of the study was to reveal molecular, morphometric and biomechanical markers of remodeled aortic wall for prediction of aortic dilation, for early diagnosis and decision making.

Two-dimensional (2D) and 2D speckle-tracking echocardiography confirmed that the dilated aorta could not produce normal movement during several cardiac cycles, which could be a predictor of possible mechanical complications (M.Bieseviciene et al. BMC Cardiovasc Disord. 2017; 17: 27).

Our study provided further evidence that FBN1 SNPs rs2118181, rs1036477, rs10519177, rs4774517, rs755251 may increase susceptibility to aortic dissections and FBN1 SNPs rs2118181 and rs1036477 to the formation of aortic aneurysms. Thus, these SNPs might be considered as biomarkers for identifying patients at risk for ascending aortic aneurysm and aortic dissection. The aortic dissection development in the absence of these risk alleles stresses that aortic dissection is a complex pathological process and various clinical and biological factors might impact its respective risk (V.Lesauskaitė et al. Eur J Cardiothorac Surg, 2015;47:e124-e130).

We reported a significant association between TGF-β1 concentration and DPAA but the mechanisms of cause and effect have not been established yet. Slightly increased TGF-β1 concentration in patients with sporadic DPAA in comparison to the reference subjects requires further investigation to establish its role in sporadic DPAA pathogenesis. We would also like to raise awareness regarding the choice of methods when measuring TGF-β1 levels with an emphasis on preanalytical phase and the choice of sample (R.Sepetiene et al. PLOSone, 2015. 10(6):e0129353).

Our study for the first time demonstrated the association between TGF-β1 levels in blood plasma and FBN1 SNPs rs2118181 and rs10519177 in a random sample of population. We suggest that TGF-β1 levels in blood plasma in combination with FBN1 SNPs might serve as a biomarker to identify patients at risk for sporadic ascending aortic aneurysm and aortic dissection (R.Sepetiene et al. Mol Med; 2015,21:735-738).

Funding: Project No. LIG-05/2012 was funded by Research Council of Lithuania.

Project duration: 2012 – 2014.

 

2. Project title: ”Personalized clopidogrel therapy according to patient genotype“

Summary of results: The main task of this project was to determine clinically important polymorphisms of the genes CYP2C19 (*1, *2 and *3), CYP2C9 (*1,*2 and *3), ABCB1 (C3435T), fibrinogen (G-455A) and (C-148T), thrombin (C494T), which influence antiplatelet effect of clopidogrel and to assess the frequency of gene polymorphisms in a random sample of Lithuanian population.
Sequence standards were determined by using Sanger sequencing of the genes CYP2C19 (*1, *2 and *3), CYP2C9 (*1,*2 and *3), ABCB1 (C3435T), fibrinogen (G-455A) and (C-148T), thrombin (C494T). Real-Time polymerase chain reaction was used to identify polymorphism of the genes CYP2C19 (*1, *2 and *3), CYP2C9 (*1,*2 and *3), ABCB1 (C3435T), fibrinogen (G-455A) and (C-148T), thrombin (C494T) in three groups of subjects: main group, group of the patients who experienced stent thrombosis and in the random population sample. We assessed the impact of represented genotypes and their variants on platelet function during antiplatelet therapy. We also assessed the influence of clinical and genetic factors (age, diabetes, concomitant drugs) on platelet function during antiplatelet therapy. We determined the most important biomarkers, who might help to identify patients of high risk of stent thrombosis. We determined CYP2C19 (*1, *2 and *3), CYP2C9 (*1,*2 and *3), ABCB1 (C3435T), fibrinogen (G-455A) and (C-148T), thrombin (C494T) polymorphisms in the random sample and we compared the frequencies of these polymorphisms with patient samples.  
We found that platelet aggregation (PA) with ADP was lower in one third of the patients who carried FI C-148C, but not in the FI T-148T genotype carriers who were treated 4 weeks after induction of treatment with aspirin and clopidogrel. CYP2C19, CYP2C9 or ABCB1 had no impact on platelet aggregation during induction or 4 weeks after induction of the treatment.
60 years and older, diabetic patients, patients having more than 90 centimeters of body waist, had higher PA values. Higher PA was observed in aspirin non-users or statin users during long-term treatment. Perindopril and zofenopril had a different effect. First one has PA lowering-effect during induction, the second one - during long-term treatment. During induction of the treatment, the use of benzodiazepines decreased PA after induction with ARA. During long-term treatment it had an opposite effect. 
CYP2C19 *2*2 was 4 times and fibrinogen TT genotype was two times more prevalent in patients who had stent thrombosis than in patients without stent thrombosis. Patients with stent thrombosis, who carried FI C-148C genotype, were older. We found a tendency that younger patients, carriers of T allele had stent thrombosis more frequently.
The prevalence of CYP2C19, ABCB1 and FI C-148T genotypes was similar in a random sample and in a sample of patients without stent thrombosis.  CYP2C19*2*2 genotype was 11 times and fibrinogen T-148T genotype was 1.7 times more prevalent in patients who had stent thrombosis than in a random sample.

Funding: Project No. MIP-038/2013 was funded by Research Council of Lithuania.

Project duration: 2013 – 2015.

 

3. Project title: ”Personalized antiplatelet therapy in patients with acute coronary symdromes: biomarkers of blood coagulation and fibrinolysis system“

Summary: Treatment of acute coronary syndromes (ACS) is not always effective. The causes are not always evident. During this project we expect to determine clinically important biomarkers, which defines antiplatelet (of clopidogrel, which is in use for about 10 years, as well as of the novel agent - ticagrelor) clinical effect in the patients who were treated for acute coronary syndromes. We believe, that the antiplatelet effect such as novel (ticagrelor), or other drugs, which are widely prescribed in clinical practice might be determined according to the activity of naturally occuring antiplatelet and other bio-active arachidonic acid metabolites which have an effect on inflammation. During this project we plan to detect 4 clinically important polymorphisms of CYP4F2, to determine enzyme activity and to investigate arachidonic acid (20-HETE) and leukotriene B4 metabolite concentrations in blood plasma. Identification of the new biomarkers might lead to proper individualization of the treatment and to improve current treatment methods for diseases, affecting the quality and healthy life.

Funding: Project No. SEN-09/2015 is funded by Research Council of Lithuania.

Project duration: 2015 – 2018.

 

4. Project title: National research programme “Healthy Ageing”: Age-related remodelling of aorta and dilatative pathology of ascending aorta: search for epigenetic biomarkers

Summary: The partner of the project: Institute of Biotechnology, Vilnius University (VU);

The research focuses on the hypothesis that there is an association between age related aortic wall remodelling and the formation of dilatative pathology of ascending aorta (DPAA). The prevalence of DPAA increases with age, therefore the underlying pathogenic mechanisms could be related. One of the mechanisms is post-transcriptional regulation of phenotypic changes in smooth muscle cells of aortic media. We aim to get a new insight into the aging processes and the mechanisms of age related diseases and to evaluate the potential of non-coding RNA (microRNA )to be used as biomarkers for DPAA and  their diagnostic capacity to predict a clinical course of aortic remodelling.

The first part of a project was dedicated to the collection of sample material and optimization of test methods. Protocols for laboratory analyses were optimized to use MirVana Ambion kit for RNA extraction and homogenising aortic tissue sample using liquid nitrogen before cell lysis. A 0.5 ml blood plasma sample was selected for RNA extraction using MirVana Paris kit. MiRNA sequencing analysis of six aortic tissue samples and five blood plasma samples showed a statistically significant increase in 18 miRNAs and decrease in 10 miRNAs expression levels in TAA samples compared to healthy aortic tissue. In current stage the role of identified miRNA in TGF-beta signaling pathway is under investigation. Only a small fraction of the identified changes in miRNA expression are published in current literature, so there is a great possibility to discover novel biomarkers for TAA.

Practical recommendation: Intervening procedures and deviation from plasma collection protocol often cause erythrocyte breakdown during blood plasma sample collection. Our findings as well as other studies show that erythrocyte specific miRNAs are released into plasma during this degradation process. This complicates evaluation on circulating miRNA expression profiles in blood, especially miRNAs present at a very low concentration levels. During optimisation of RNA extraction method from blood plasma we have established that only in plasma samples which had absorption at a 414 nm wavelength (A414) lower than 0.2, erythrocyte haemolysis did not interfere with miRNA expression analyses. Later in the study we have noticed that this value is strongly associated with other blood characteristics (i.e. lipid concentration in blood, use of medicine) and can increase above 0.2 even if haemolysis in blood plasma is not present. Taken into consideration these factors, when evaluating haemolysis levels, it is necessary to assess expression of miRNAs associated with erythrocyte: miR-16-5p and miR-451a-5p, since their concentration is dependent on the level of haemolysis. Summing up these results we recommend to check erythrocyte haemolysis level in selected blood plasma samples before carrying out miRNA expression analysis ( miRNA sequencing, identification and validation of potential biomarkers) using the following methods: measuring plasma sample absorption (A414), checking erythrocyte associated miRNA expression levels, and analysing samples which do not have haemolysis.

Funding: Project No. SEN-05-2016 is funded by Research Council of Lithuania.

Project duration: 2016 – 2018.

 

5. Project title: ”Point-of-Care method for ticagrelor pharmacogenomics (OPTOGEN)“

Summary: The aim of the project is to develop a new device that will allow to individualize treatment with ticagrelor "Point-of-Care" and, during the prospective research in the patients prescribed antiplatelet drugs, to validate a new bio-marker for the treatment individualization with ticagrelor. The project will be implemented in stages.

During the first stage, a rapid genotyping method and dedicated equipment will be developed. That will allow to detect a selected bio-marker in one tube without DNA extraction. In the second stage, prospective studies will be carried out with the patients before antiplatelet therapy prescription (n = 100). During this stage, the prognostic value of the selected biomarker will be evaluated for further individualization of the treatment with ticagrelor. The research will be carried out according to the following principle: the patient`s genotype will be determined prior to the antiplatelet prescription, depending on the results of the genotyping. Thus, a patient will receive an individualized therapy depending on the genotyping results (ticagrelor or alternative drug) and the recommended dosage.

Results of the project: During the project the impact of a bio-marker involved in ticagrelor pharmacogenomics will be determined. A newly developed device will be applied for a patent in European Patent Office. The obtained scientific results (excluding the final report of the project) will be published in at least one research journal with impact factor higher than 2.

The use of the results of this project are obvious in the Lithuanian and in global scale, as these results will allow to proper dosage one of the most commonly used anti-platelet drugs, which are currently used in clinical practice and will help to prevent the undesirable effects of drug usage. Both the developed method and device would be also used in a wider circle of researchers. The results of the project will be implemented through direct contact with physicians and scientists working in the mentioned area. The results will be made available to the public through social networks.

Funding: Project No. 01.2.2-LMT-K-718-01-0038 is funded by European Regional Development Fund.

Project duration: 2017 – 2021.

 

 

6. Project title: ”Centre of Excellence in Science and Technology for Healthy Ageing (HEALTH-TECH)“

Summary: Centre of Excellence in Science and Technology for Healthy Ageing is under development by Kaunas University of Technology,LithuanianUniversityof Health Sciences, andVilniusUniversitywith support by partners of the Baltic Sea region- Teknologian Tutkimuskeskus VTT (VTT) inFinland,UniversityofLundinSweden.

In the context of ageing populations inEuropeand many other countries around the world, high impacting challenges are expected to hit societies and economies. Among them, the growing phenomenon of multi-morbidity (MM), which is the simultaneous occurrence of several non-communicable diseases (NCDs) in a patient, is a major concern. MM is still poorly addressed in medical care and treatment, since the standard approaches focus on single-disease diagnostics and treatments. Yet, MM is a major concern for patients, whose quality of life is significantly impaired, social inclusion impacted, and risk of death increased. It also critically affects the economy, through the resulting high cost of healthcare, the poverty many MM patients face, or the reduced labour participation MM causes.

The problem of MM opens a major route for research, as a better understanding is required. It also brings important innovation opportunities, since solutions for prevention, diagnostics, care and treatment of MM must be developed.

The proposal was aimed to address the problem of MM by  preparing the business plan proposing the creation of a Centre of Excellence (CoE) inLithuanianamed Health-Tech.

Health-Tech’s vision is to become a leading Baltic Sea Region CoE of advance knowledge-based innovations for prediction, early diagnostics and personalised management of MM of ageing persons, with the aim to enhance their quality of life and improve the effectiveness of healthcare systems. The Health-Tech CoE will have a particular focus on collaboration with global healthy ageing research and innovation networks.

Health-Tech’s mission is 1) to provide international and interdisciplinary leadership, to create and transfer advanced knowledge, technology and integrated solutions for prediction, early diagnostics and personalised management of multi-morbidity of ageing persons; 2) to foster talents of new generation of innovation-oriented researchers and professionals; 3 to promote management of MM among ageing persons, their families and across different levels of the healthcare system.

The CoE is founded by five higher education and research partners: three fromLithuania(Kaunas University of Technology, LithuanianUniversityofHealth Sciences,VilniusUniversity), one fromSweden(LundUniversity), and one fromFinland(VTT Technical Research Centre of Finland). The five partners will, through a Joint Activity Agreement, establish the CoE according to a Long-Term Research and Innovation Strategy. The clinical focus will be four types of disease (cardio-vascular diseases (CVD); bone and joint diseases; neurodegenerative diseases (ND); and gastrointestinal dysfunction), and the research focus will be on four themes:

Genomics and proteins structures and functions for personalised management of MM patterns.

Personalised sets of multifactorial biomarkers for early diagnostics of MM patterns.

Multimodal biosignal, imaging and IT for personalised early diagnostics and monitoring of MM patterns.

Tissue engineering in age-related MM management.

Prepared business plan will applied for Horizont 2020 call.

Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 664339.

 

Main publications:

2018 – 2017

1. A novel ultrasonic method for evaluation of blood clotting parameters. Vacis Tatarunas, Algirdas Voleisis, Reimondas Sliteris, Rymantas Kazys, Liudas Mazeika, Vaiva Lesauskaite. Journal of medical ultrasonics. Tokyo: Springer Japan. (Original article). ISSN 1346-4523. 2018, vol. 00, no. 00, p. 00-00. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.471. Internet access
2. MMP-2 Rs24386 (C-->T) gene polymorphism and the phenotype of age-related macular degeneration. Rasa Liutkeviciene, Vaiva Lesauskaite, Giedre Sinkunaite-Marsalkiene, Sandrita Simonyte, Reda Zemaitiene, Loresa Kriauciuniene, Dalia Zaliuniene. International journal of ophthalmology. Xi'an, China: Press of International Journal of Ophthalmology (IJO PRESS). (Basic research). ISSN 2222-3959. 2017, vol. 10, no. 9, p. 1349-1383. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 0.495. Internet access
3. Traditional risk factors of acute coronary syndrome in four different male populations – total cholesterol value does not seem to be relevant risk factor. J. A. Hubacek, V. Stanek, M. Gebauerova, V. Adamkova, V. Lesauskaite, D. Zaliaduonyte-Peksiene, A. Tamosiunas, A. Supiyev, A. Kossumov, A. Zhumadilova, J. Pitha. Physiological research. Prague: Institute of Physiology of the Czech Academy of Sciences. ISSN 0862-8408. 2017, vol. 66, suppl. 1, p. S121-S128. Science Citation Index Expanded (Web of Science); 0.445. Internet access
4. SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area. Daiva Stanislovaitiene, Dalia Zaliuniene, Algimantas Krisciukaitis, Robertas Petrolis, Alina Smalinskiene, Vita Lesauskaite, Abdonas Tamosiunas, Vaiva Lesauskaite. Ophthalmic genetics. London: Informa Healthcare. ISSN 1381-6810. 2017, vol. 38, no. 3, p. 233-237. Science Citation Index Expanded (Web of Science); MEDLINE; 0.65. Internet access
5. Prevalence of O25b-ST131 clone among Escherichia coli strains producing CTX-M-15, CTXM- 14 and CTX-M-92 β-lactamases. Agnė Giedraitienė, Astra Vitkauskienė, Alvydas Pavilonis, Vaiva Patamsytė, Nathalie Genel, Dominique Decre, Guillaume Arlet. Infectious diseases. Abingdon, England: Taylor & Fransis Ltd. (Original article). ISSN 2374-4235. 2017, vol. 49, no. 2, p. 106-112. Science Citation Index Expanded (Web of Science); MEDLINE; Index Veterinarius; 0.35. Internet access
6. Two-dimensional speckle-tracking echocardiography for evaluation of dilative ascending aorta biomechanics. Monika Bieseviciene, Jolanta Justina Vaskelyte, Vaida Mizariene, Rasa Karaliute, Vaiva Lesauskaite, Raimonda Verseckaite. BMC cardiovascular disorders. London: BioMed Central. (Research article). ISSN 1471-2261. 2017, vol. 17, no. 1, p. 1-11. Science Citation Index Expanded (Web of Science); MEDLINE; 0.471. Internet access
7. The Impact of clinical and genetic factors on ticagrelor and clopidogrel antiplatelet therapy. Vacis Tatarunas, Nora Kupstyte, Remigijus Zaliunas, Agne Giedraitiene, Vaiva Lesauskaite. Pharmacogenomics. London: Future Medicine. (Research article). ISSN 1462-2416. 2017, vol. 18, no. 10, p. 969-979. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.693. Internet access
8. The Impact of CYP2C19*2, CYP4F2*3, and clinical factors on platelet aggregation, CYP4F2 enzyme activity, and 20-hydroxyeicosatetraenoic acid concentration in patients treated with dual antiplatelet therapy. Vacis Tatarunas, Nora Kupstyte, Agne Giedraitiene, Vilius Skipskis, Valdas Jakstas, Vaidotas Zvikas, Vaiva Lesauskaite. Blood coagulation & fibrinolysis. London: Lippincott, Williams & Wilkins. (Original article). ISSN 0957-5235. 2017, vol. 28, no. 8, p. 658-664. Science Citation Index Expanded (Web of Science); MEDLINE; 0.742. Internet access
9. Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents. Sandrita Simonyte, Renata Kuciene, Jurate Medzioniene, Virginija Dulskiene, Vaiva Lesauskaite. BMC medical genetics. London: BioMed Central. (Research article). ISSN 1471-2350. 2017, vol. 18, no. 1, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; Scopus; 1. Internet access
10. Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development. Diana Žaliaduonytė-Pekšienė, Vaiva Lesauskaitė, Rasa Liutkevičienė, Vytenis Tamakauskas, Vilius Kviesulaitis, Giedrė Šinkūnaitė-Maršalkienė, Sandrita Šimonytė, Simonita Mačiulskytė, Eglė Tamulevičiūtė-Prascienė, Olivija Gustienė, Abdonas Tamošiūnas, Remigijus Žaliūnas. Journal of the renin-angiotensin-aldosterone system. London: Sage. (Original article). ISSN 1470-3203. 2017, vol. 18, no. 4, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 0.433. Internet access
11.  MiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing. Ugne Gyvyte, Simonas Juzenas, Violeta Salteniene, Juozas Kupcinskas, Lina Poskiene, Laimutis Kucinskas, Sonata Jarmalaite, Kristina Stuopelyte, Ruta Steponaitiene, Georg Hemmrich-Stanisak, Matthias Hübenthal, Alexander Link, Sabine Franke, Andre Franke, Dalia Pangonyte, Vaiva Lesauskaite, Limas Kupcinskas, Jurgita Skieceviciene. Oncotarget. Albany, N.Y.: Impact Journals. ISSN 1949-2553. 2017, vol. 8 no. 23, p. 37225-37238. [Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.351. Internet access
12. The Effect of sodium valproate on the glioblastoma U87 cell line tumor development on the chicken embryo chorioallantoic membrane and on EZH2 and P53 expression. Dovilė Kavaliauskaitė, Donatas Stakišaitis, Justė Martinkutė, Lina Šlekienė, Arūnas Kazlauskas, Ingrida Balnytė, Vaiva Lesauskaitė, Angelija Valančiūtė. BioMed research international. New York: Hindawi Publishing Corporation. (Research article). ISSN 2314-6133. 2017, vol. 2017, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; Scopus; 0.25. Internet access
13. Investigation of TGFβR2 SNP rs4522809, Osteopontin, TGF β1 and their association with dilatative pathology of ascending thoracic aorta. Zivile Staneviciute, Ramune Sepetiene, Ingrida Grabauskyte, Vaiva Patamsyte, Vaiva Lesauskaite. Cytokine. Oxford: Elsevier. ISSN 1043-4666. 2017, vol. 00, no. 00, p. 00-00. Science Citation Index Expanded (Web of Science); MEDLINE; 0.8. Internet access

 2016

1. Physical activity, but not dietary intake, attenuates the effect of the FTO rs9939609 polymorphism on obesity and metabolic syndrome in Lithuanian adult population. J. Petkeviciene, A. Smalinskiene, J. Klumbiene, V. Petkevicius, V. Kriaucioniene, V. Lesauskaite. Public health. Amsterdam: Elsevier. (Original research). ISSN 0033-3506. 2016, vol. 135, p. 23-29. Science Citation Index Expanded (Web of Science); MEDLINE; BIOSIS; Excerpta Medica; Scopus; 0.471. Internet access
2. Multiplicity of effects and health benefits of resveratrol. Lolita Kuršvietienė, Inga Stanevičienė, Aušra Mongirdienė, Jurga Bernatonienė.  Medicina. Wrocław: Elsevier. (Reviews). ISSN 1010-660X. 2016, vol. 52, no. 3, p. 148-155. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.433. Internet access
3. Role of MMP-2 (-1306 C/T) polymorphism in age- related macular degeneration. Rasa Liutkeviciene, Vaiva Lesauskaite, Diana Zaliaduonyte-Peksiene, Giedre Sinkunaite-Marsalkiene, Dalia Zaliuniene, Vaida Mizariene, Olivija Gustiene, Vytautas Jasinskas, Abdonas Tamosiunas. Ophthalmic genetics. London: Informa Healthcare. (Research report). ISSN 1381-6810. 2016, vol. 37, no. 2, p. 170-176. Science Citation Index Expanded (Web of Science); MEDLINE; 0.385. Internet access
4. Gene polymorphism of CYP2C19*2, *3 and CYP3A4*1B and early stent thrombosis: case reports and literature review. Nazgul Kulmyrzaeva, Vacis Tatarunas, Vilius Skipskis, Gaziza Smagulova, Nazgul Seitmaganbetova, Audrone Veikutiene, Vaiva Lesauskaite. Personalized medicine. London: Future Medicine. (Case series). ISSN 1741-0541. 2016, vol. 13, no. 5, p. 423-428. Science Citation Index Expanded ( Web of Science); 0.808. Internet access

2015

1. Characteristics of expression of matrix metalloproteinases (MMP-2 and MMP-9) in glottic squamous cell carcinoma and benign vocal fold lesions. Uloza V, Liutkevicius V, Pangonyte D, Lesauskaite V. Clinical and experimental otorhinolaryngology. Seoul: Korean Society of Otorhinolaryngology-Head and Neck Surgery. (Original article). ISSN 1976-8710. 2015, vol. 8, no. 1, p. 57-64. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Synapse; 0.707. Internet access
2. Effect of physical training on indices of platelet aggregation and fibrinogen concentration in patients with chronic heart failure. Aušra Mongirdienė, Raimondas Kubilius. Medicina. Wrocław: Elsevier. (Original research article). ISSN 1010-660X. 2015, vol. 51, no. 6, p. 343-350. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.707. Internet access
3. The Role of matrix metalloproteinases polymorphisms in age-related macular degeneration. Liutkeviciene R, Lesauskaite V, Sinkunaite-Marsalkiene G, Zaliuniene D, Zaliaduonyte-Peksiene D, Mizariene V, Gustiene O, Jasinskas V, Jariene G, Tamosiunas A. Ophthalmic genetics. London: Informa Healthcare. ISSN 1381-6810. 2015, vol. 36, no. 2, p. 149-155. Science Citation Index Expanded (Web of Science); MEDLINE; 0.52. Internet access
4. Exogenous connexin43-expressing autologous skeletal myoblasts ameliorate mechanical function and electrical activity of the rabbit heart after experimental infarction. Antanavičiūtė I, Ereminienė E, Vysockas V, Račkauskas M, Skipskis V, Rysevaitė K, Treinys R, Benetis R, Jurevičius J, Skeberdis VA. International journal of experimental pathology. Oxford, OX: Blackwell Scientific Publications. (Original article). ISSN 0959-9673. 2015, vol. 96, no. 1, p. 42-53. Science Citation Index Expanded (Web of Science); MEDLINE; Index Veterinarius; CAB Abstracts® (CABI); 1.342. Internet access
5. FBN1 polymorphisms in patients with the dilatative pathology of the ascending thoracic aorta. Lesauskaite V, Sepetiene R, Jariene G, Patamsyte V, Zukovas G, Grabauskyte I, Stanioniene Z, Sirmenis R, Benetis R. European journal of cardio-thoracic surgery. Kidlington, Oxford, UK: Elsevier Science. ISSN 1010-7940. 2015, vol. 47, no. 4, p. e124-e130. Science Citation Index Expanded (Web of Science); MEDLINE; 1.556. Internet access
6. Effect of clinical factors and gene polymorphism of CYP2C19*2, *17 and CYP4F2*3 on early stent thrombosis. Kupstyte N, Zaliunas R, Tatarunas V, Skipskis V, Zaliaduonyte-Peksiene D, Grabauskyte I, Dovidaitiene D, Bumblauskas K, Gustiene O, Lesauskaite V. Pharmacogenomics. London: Future Medicine. (Research article). ISSN 1462-2416. 2015, vol. 16, no. 3, p. 181-189. cience Citation Index Expanded (Web of Science); MEDLINE; Biological Abstracts; BIOSIS Previews; Prous Science Integrity®; Scopus; 0.693. Internet access
7. Blood plasma TGF- β1 concentration in sporadic dilatative pathology of ascending aorta: more questions than answers. Sepetiene R, Patamsyte V, Zukovas G, Jariene G, Stanioniene Z, Benetis R, Lesauskaite V. PloS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2015, vol. 10, no. 6, p. 1-7. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; Chemical Abstracts Service (CAS); AGRICOLA; PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; 1.485. Internet access
8. The Effect of PAI-1 4G/5G polymorphism and clinical factors on coronary artery occlusion in myocardial infarction. Parpugga TK, Tatarunas V, Skipskis V, Kupstyte N, Zaliaduonyte-Peksiene D, Lesauskaite V. Disease markers. New York: Hindawi Publishing Corporation. (Research article). ISSN 0278-0240. 2015, vol. 2015, p. 1-8. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.866. Internet access
9. Association between fibrillin1 polymorphisms (rs2118181, rs10519177) and transforming growth factor β1 concentration in human plasma. Ramune Sepetiene, Vaiva Patamsyte, Giedrius Zukovas, Giedre Jariene, Zita Stanioniene, Rimantas Benetis, Abdonas Tamosiunas, Vaiva Lesauskaite. Molecular medicine. Manhasset, NY: Feinstein Institute for Medical Research. ISSN 1076-1551. 2015, vol. 21, p. 735-738. Science Citation Index Expanded (Web of Science); MEDLINE; 1.516. Internet access

2014

1. Local and systemic immune responses in gingivitis and periodontitis. Gediminas Zekonis, Ingrida Barzdziukaite, Jonas Zekonis, Renata Sadzeviciene, Sandrita Simonyte, Juozas Zilinskas. Central European Journal of Medicine. Berlin: Springer. (Research article). ISSN 1895-1058. 2014, vol. 9, iss. 5, p. 694-703. Science Citation Index Expanded (Web of Science); Global Health; IndexCopernicus; Scopus; 0.289. Internet access
2. The Effect of CYP2C9, VKORC1 and CYP4F2 polymorphism and of clinical factors on warfarin dosage during initiation and long-term treatment after heart valve surgery. Tatarunas V, Lesauskaite V, Veikutiene A, Grybauskas P, Jakuska P, Jankauskiene L, Bartuseviciute R, Benetis R. Journal of thrombosis and thrombolysis. [Dordrecht ; Norwell, MA]: Kluwer Academic Publishers. ISSN 0929-5305. 2014, vol. 37, no. 2, p. 177-185. Science Citation Index Expanded (Web of Science); MEDLINE; 0.707. Internet access
3. Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene. Zaliaduonyte-Peksiene D, Simonyte S, Lesauskaite V, Vaskelyte J, Gustiene O, Mizariene V, Jurkevicius R, Jariene G, Tamosiunas A, Zaliunas R. Journal of the renin-angiotensin-aldosterone system : JRAAS. London: SAGE Publications. ISSN 1470-3203. 2014, vol. 15, no. 3, p. 286-293. Science Citation Index Expanded (Web of Science); MEDLINE; 0.866. Internet access
4. The Role of clinical parameters and of CYP2C19 G681 and CYP4F2 G1347A polymorphisms on platelet reactivity during dual antiplatelet therapy. Tatarunas V, Jankauskiene L, Kupstyte N, Skipskis V, Gustiene O, Grybauskas P, Lesauskaite V.  Blood coagulation & fibrinolysis. London: Lippincott Williams And Wilkins. ISSN 0957-5235. 2014, vol. 25, no. 4, p. 369-374. Science Citation Index Expanded (Web of Science); MEDLINE; 0.742. Internet access
5. Effect of Acanthopanax senticosus on the accumulation of cadmium and on the immune response of spleen cells. Smalinskiene A, Savickiene N, Zitkevicius V, Pangonyte D, Sadauskiene I, Kasauskas A, Ivanov L, Lesauskaite V, Savickas A, Rodovičius H. Journal of toxicology and environmental health. Part A. Philadelphia: Taylor & Francis. ISSN 1528-7394. 2014, vol. 77, no. 21, p. 1311-1318. Science Citation Index Expanded (Web of Science); MEDLINE; CAB Abstracts; 0.52. Internet access
6. Physical, behavioural and genetic predictors of adult hypertension: the findings of the Kaunas cardiovascular risk cohort study. Petkeviciene J, Klumbiene J, Simonyte S, Ceponiene I, Jureniene K, Kriaucioniene V, Raskiliene A, Smalinskiene A, Lesauskaite V. PLoS One. San Francisco: Public Library of Science. ISSN 1932-6203. 2014, vol. 9, no. 10, p. 1-9. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Chemical Abstracts Service (CAS); PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; DOAJ; 0.577. Internet access

2013

1. The Effect of Polyscias filicifolia Bailey biomass tincture on the protein synthesis process in the heterogeneous system from the isolated pig heart. Artūras Kašauskas, Aušra Mongirdienė. Medicina. Kaunas: Lietuvos sveikatos mokslų universitetas. (Experimental investigation). ISSN 1010-660X. 2013, t. 49, Nr. 6, p. 278-283. Science Citation Index Expanded (Web of Science); MEDLINE; IndexCopernicus; Scopus; 0.707. Internet access
2. SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner. Stanislovaitiene D, Lesauskaite V, Zaliuniene D, Smalinskiene A, Gustiene O, Zaliaduonyte-Peksiene D, Tamosiunas A, Luksiene D, Petkeviciene J, Zaliunas R. Lipids in health and disease. [London]: BioMed Central. ISSN 1476-511X. 2013, vol. 12, p. 1-8. Science Citation Index Expanded (Web of Science); MEDLINE; CABI; Food Science and Technology Abstracts; Scopus; 0.693. Internet access
3. Association between APOE, SCARB1, PPAR alpha polymorphisms and serum lipids in a population of Lithuanian adults. Smalinskiene A, Petkeviciene J, Luksiene D, Jureniene K, Klumbiene J, Lesauskaite V. Lipids in health and disease. [London]: BioMed Central. ISSN 1476-511X. 2013, vol. 12, p. 1-8. Science Citation Index Expanded (Web of Science); MEDLINE; CABI; CAS; Food Science and Technology Abstracts; Scopus; 0.943. Internet access
4. Polyacrylamide gels with ionized functional groups in their selective recognition of trimeric molecular form of human growth hormone. Rimantas Kublickas, Giedrė Jarienė. Polymer bulletin. New Yor: Springer. (Original paper). ISSN 0170-0839. 2013, vol. 70, no. 3, p. 985-992. [Science Citation Index Expanded (Web of Science); Scopus; Materials Science Citation Index; VINITI - Russian Academy of Science; 0.866. Internet access

 

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Research group

Contacts
Website

The Research Group supervised by Prof. habil. dr. Feliksas F. Bukauskas was established in April 2015 and was incorporated into the Laboratory of Molecular Cardiology. Professor Feliksas Bukauskas was awarded by association „Global Lithuanian Leaders“ for „implementation of international innovations in Lithuania“ in December 2016. Nomination video   Article

 

Professor habil. dr. Feliksas Bukauskas and the President of Lithuania Dalia Grybauskaitė during the event „Global Lithuanian Awards“. Photographer – Martynas Zaremba.

 

Research topics of the research group:

The properties and functional role of gap junction channels, formed of connexin protein, in shaping behaviour of cardiovascular and neural circuits under normal and pathological conditions:

1. Structure-function studies of connexin-based channels.
2. Voltage and chemical gating of gap junction channels.
3. Modeling and experimental studies of cardiac and neuronal networks.

 

Personnel:

Vytautas Kazimieras Verselis prof. dr. , chief researcher

Lina Rimkutė dr. , senior researcher

Tadas Kraujalis dr. , researcher

Mindaugas Šnipas dr. , senior researcher

Kęstutis Maciūnas, junior researcher / PhD student

Lukas Gudaitis, PhD student

 

Projects:

1. Project title: “Structure-function studies of pH sensitivity of gap junction channels” 

Project objective: structure-function studies of gap junction (GJ) channels sensitivity to intracellular pH_i and expanding a gating model of GJ channels by including a dependence not only on V_j but also on pH_i.

Summary:

The major goal - structure-function studies of gap junction (GJ) channels sensitivity to acidosis. GJs are formed of connexin (Cx) protein and are responsible for electrical and metabolic cell-cell communication. Experiments will be performed in coupling-deficient RIN cells transfected with Cx36 and Cx43. Junctional conductance (gj) under normal and variety of experimental conditions will be measured in cell pairs using a dual whole-cell voltage clamp. Our reported and preliminary data show that acidification increases the open channel probability of Cx36 GJs expressed by neurons and pancreatic ß-cells what determines their resistance to intracellular pH (pHi) decay to ~6 during ischemia. On the contrary, Cx43 GJs expressed in astrocytes and cardiomyocytes, are fully blocked at pHi=~6. We have shown that GJs contain 'fast' and 'slow' gates, which determine modulation of GJs depending on transjunctional voltage (Vj), pHi and others factors. Our data show that differences in sensitivity among Cx36 and Cx43 GJs to pHi are defined by differences in the sequence of amino acid (AA) in the N-terminus (NT) of Cxs. To determine Cx domains that are responsible for sensitivity to pH, we will study mutants in which AAs will be replaced among Cx36 and Cx43 individually or in groups. By measuring gj and its steady-state dependence of on Vj at different pHi, we will examine influence of pHi on fast and slow gates. This will allow us to detail domains in the NT region that are responsible for differences in sensitivity to pHi among Cx36 and Cx43. The data will be analysed using a gating model of GJ channels (GMGJC). In doing so, we will expand our reported GMGJC including a dependence not only on Vj but also on pHi. A principal concept of this model and its viability was demonstrated during two conferences (2012 & 2014). Altogether, proposed studies will determine AAs serving as pH-sensor/s, and will allow to find whether pHi influence gj by acting on fast, slow, or both gates.

Funding: Project No. MIP-76/2015 was funded by Research Council of Lithuania.

Project duration: 2015 – 2017.

 

2. Project title: „Study of connexin 26 mutations in syndromic deafness“

Project objective: To improve professional skills of researchers with PhDs and encourage the planning and implementation of high level research projects.

Summary:

Mutation of the connexin 26 (Cx26) gap junction (GJ) channel protein is the most common cause of congenital, sensorineural deafness in humans. Although studies have established that deletion of Cx26 from the cochlear sensory epithelium produces deafness, the role Cx26 plays to maintain hearing remains uncertain.  Complicating an understanding of the role of Cx26 is two functional channel configurations that serve very different tissue functions. GJ channels are formed by the docking of two hemichannels and serve as pathways for direct electrical and chemical signaling between cells. Undocked hemichannels can also function and mediate signaling across the plasma membrane. A number of Cx26 missense mutations with retained channel function also cause deafness that is often syndromic, such as in keratitis-ichthyosis-deafness (KID) syndrome, in which hearing loss is accompanied by serious skin disorders. A leading hypothesis is that the pathogenesis of KID and other Cx26-linked syndromes is the result of aberrantly-functioning hemichannels that alter transmembrane signaling and compromise cell integrity. The common association of KID mutants with the aqueous pore suggests that altered permeability characteristics may be principal contributors to disease. Purinergic signaling and Ca2+play prominent roles in the cochlea and skin and here we investigate how two KID mutants, G45E and D50N, differentially affect Ca2+ influx, ATP release and subsequent signaling to adjacent cells. We use mammalian cell expression systems to quantify effects under conditions of defined Cx expression and coupling geometry. We extend to these studies to native cells using keratinocytes and cochlear explant cultures isolated from transgenic animals carrying the G45E mutation.  Overall, we view that this work will have a major impact in understanding Cx26-linked syndromic deafness as well as a growing list of disorders in which aberrant Cx channels underlie tissue dysfunction.

Funding: Funded by European Union fund investment operational programme “09.3.3-LMT-K-712 Development of scientific competences of scientists, other researchers and students through practical research activities”.

Project duration: 2017-2019.

Postdoctoral fellow: Dr. Lina Rimkutė.

Fellowship supervisor: Prof. dr. Vytautas K. Verselis.

 

 

3. Project title: „Modeling voltage gating properties of gap junction channels, formed of connexin protein“

Funding: Project is being funged by science project competition award of the association „Santakos slėnis“.

Project duration: 2018-03-20 – 2018-12-31.

 

Publications of the research group:

The full list of Prof. habil. dr. Feliksas Bukauskas publications can be found here. 

 

2016 - 2018

1. Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions. Lina Rimkute, Tadas Kraujalis, Mindaugas Snipas, Nicolas Palacios-Prado, Vaidas Jotautis, Vytenis A. Skeberdis, Feliksas F. Bukauskas. Front. Physiol., 12 April 2018. https://doi.org/10.3389/fphys.2018.00362. Internet access
2. Molecular basis for potenentiation of Cx36 gap junction channel conductance by n-alcohols and general anesthetics. Vytautas Raškevičius, Vaidas Jotautis, Lina Rimkutė, Alina Murandykina, Mintautė Kazokaitė, Visvaldas Kairys, Vytenis Arvydas Skeberdis. Bioscience Reports (2018) 38 BSR20171323. Published online 2018 Feb 8. Prepublished online 2018. doi:  10.1042/BSR20171323. Internet access
3. Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating. Mindaugas Snipas, Lina Rimkute, Tadas Kraujalis, Kestutis Maciunas, Feliksas F. Bukauskas. PLoS computational biology. San Francisco: Public Library of Science. (Research article). ISSN 1553-734X. 2017, vol. 13, no. 4, p. 1-26. Internet access
4. An acute mouse spinal cord slice preparation for studying glial activation ex vivo. Juan Mauricio Garré, Guang Yang, Feliksas F. Bukauskas, Michael V. L. Bennett. Bio-protocol. Sunnyvale, CA: Bio-protocol LLC. ISSN 2331-8325. 2017, vol. 7, no. 2, p. 1-10. Internet access
5. Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis. Kucheryavykh Lilia Y, Benedikt Jan, Cubano Luis A, Skatchkov Serguei N, Bukauskas Feliksas F, Kucheryavykh Yuriy V. Neuroreport. Philadelphia: Lippincott Williams & Wilkins. ISSN 0959-4965. 2017, vol. 28, no. 4, p. 208-2013. Internet access
6. Stochastic model of gap junctions exhibiting rectification and multiple closed states of slow gates. Mindaugas Snipas, Tadas Kraujalis, Nerijus Paulauskas, Kestutis Maciunas, Feliksas F. Bukauskas. Biophysical journal. Cambridge, MA: Cell Press. ISSN 0006-3495. 2016, vol. 110, no. 6, p. 1322-1333. Internet access
7. Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels. Kestutis Maciunas, Mindaugas Snipas, Nerijus Paulauskas, Feliksas F. Bukauskas. Journal of general physiology. New York: Rockefeller University Press. (Research article). ISSN 0022-1295. 2016, vol. 147, iss. 3, p. 273-288. Internet access
8. FGF-1 triggers pannexin-1 hemichannel opening in spinal astrocytes of rodents and promotes inflammatory responses in acute spinal cord slices. Juan Mauricio Garré, Guang Yang, Feliksas F. Bukauskas, Michael V. L. Bennett. Journal of neuroscience. Washington, DC: Society for Neuroscience. ISSN 0270-6474. 2016, vol. 36, no. 17, p. 4785-4801. Internet access
9. The Role of neural connexins in HeLa cell mobility and intercellular communication through tunneling tubes. Lina Rimkutė, Vaidas Jotautis, Alina Marandykina, Renata Sveikatienė, Ieva Antanavičiūtė, Vytenis Arvydas Skeberdis. BMC cell biology. London: Biomed Central Ltd. (Research article). ISSN 1471-2121. 2016, vol. 17, no. 1, p. 1-12. Internet access
10. Differences in the control of basal L-type Ca2+ current by the cyclic AMP signaling cascade in frog, rat, and human cardiac myocytes. Rimantas Treinys, Andrius Bogdelis, Lina Rimkutė, Jonas Jurevičius, Vytenis Arvydas Skeberdis. Journal of physiological sciences : JPS. Tokyo: Springer. (Original paper). ISSN 1880-6546. 2016, vol. 66, no. 4, p. 327-336. Internet access

2013 - 2015

1. Application of stochastic automata networks for creation of continuous time markov chain models of voltage gating of gap junction channels. Mindaugas Snipas, Henrikas Pranevicius, Mindaugas Pranevicius, Osvaldas Pranevicius, Nerijus Paulauskas, Feliksas F. Bukauskas. BioMed research international. New York: Hindawi Publishing Corporation. (Research article). ISSN 2314-6133. 2015, vol. 2015, p. 1-13. Internet access
2. Continuous time Markov chain models of voltage gating of gap junction channels. Henrikas Pranevicius, Mindaugas Pranevicius, Osvaldas Pranevicius, Mindaugas Snipas, Nerijus Paulauskas, Feliksas Bukauskas. Information technology and control = Informacinės technologijos ir valdymas / Kaunas: KTU. ISSN 1392-124X. 2014, vol. 43, no. 2, p. 133-142. Internet access
3. Regulation of connexin-36 gap junction channels by n-alkanols and arachidonic acid. Marandykina A, Palacios-Prado N, Rimkute L, Skeberdis VA, Bukauskas FF. Journal of physiology. Oxford: Wiley. ISSN 0022-3751. 2013, vol. 591, part 8, p. 2087-2101. Internet access
4. Magnesium-dependent modulation of junctional conductance and gating properties of Connexin36 Gap junction channels. Nicolas Palacios-Prado, Alina Marandykina, Lina Rimkute, Sandrine Chapuis, Nerijus Paulauskas, Vytenis A. Skeberdis, John O’Brien, Michael V.L. Bennett, Feliksas F. Bukauskas. Biophysical Journal : 57th Annual Meeting: February 2-6, 2013, Philadelphia, Pennsylvania / Biophysical Society. New York ; Cambridge: Biophysical Society Published by Elsevier Inc. (Wednesday, February 6, 2013.). ISSN 0006-3495. 2013, vol. 104, iss. 2, suppl. 1, p. 631a, no. 3245-Pos Board B400. Internet access

 

Laboratory of Membrane Biophysics

 Jonas Jurevičius,

Head of laboratory, Head researcher, tel. 302877,

e-mail: jonas.jurevicius@lsmuni.lt.

Personnel:

 Regina Mačianskienė dr., Head researcher

 Irma Martišienė dr. , Researcher

 Rimantas Treinys dr.,Senior researcher

 Mantė Almanaitytė, Junior researcher

 Inga Andriulė, Junior researcher

 Antanas Navalinskas,  Senior engineer

 Vanda Burbulytė,  Engineer

 Kęstutis Runkevičius,  Engineer

 Virginija Luckienė, preparator

 

The main research activities of the laboratory

• Remodeling of ion channels and intracellular communication in the heart
• Novel mechanisms of arrhythmias – from the cell to the whole heart
• Development of new imaging modalities for optical mapping in vivo and obtaining proof-of-concept of novel therapeutic approaches.

 We investigate what’s changes in electrophysiological properties of ion channels (Na⁺, L-type Ca²⁺, various K⁺, and novel TRPM7, etc.) in the heart with ischemia, arrhythmias, heart failure, etc.: current density, kinetics, sensitivity to pharmacological regulation. Using biophysical, molecular and pharmacological approaches we elucidate ion channel function under physiological and pathological conditions and its relationship to cell signaling.

We develop new imaging modalities for evaluation of optical/electrical signal in vivo, and evaluate evolution of possible mechanisms of arrhythmias, induced by ischemia, in particular, changes of electrical signal in different cell layers of myocardium (on Langendorf-perfused heart from animal model): sensitivity to ischemia, changes in both ion channels and membrane potential, in interaction between ischemia and remodeling of ion channels, in intracellular communication, in electrical wave propagation upon ischemia in various cell layers, in sensitivity to pharmacological drugs. We evaluate what of them are more pronounced, and how the origin of arrhythmias could be affected; this could change strategy for treatment of various ventricular arrhythmias.

In cooperation with dr. Rodolphe Fischmeister (The Faculty of Pharmacy, at 11^th University of Paris, France), we study cellular and molecular mechanisms of calcium signaling in ischemic myocardium and β-adrenergic regulation of L-type calcium current of experimental animals and human heart.

In cooperation with dr. Arkady M. Pertsov (SUNY Upstate Medical University, Department of Pharmacology, Syracuse, NY, USA), we gather the scientific and technological approaches. We developed of in situ optical mapping model (mapping of “non-explanted heart”) in small (rabbits) and big (pigs) animals as well as the problems of the usage of NIR probes in blood-perfused myocardium. Such experimental design is completely new and optical mapping experiments of the heart in situ have not been performed. We study mechanisms and dynamics of T-wave alternans in ischemic heart models (Langendorff-perfused and in situ (intact) hearts during induced ischemia).

In cooperation with dr. Kanigula Mubagwa (The Katholic University of Leuven, Belgium) we investigate cellular and molecular mechanisms of the TRPM7 cation channels and of intracellular magnesium in the failing myocardium.

Technical facilities of the laboratory enable us to perform collaborative research projects with other laboratories working in different scientific fields. In the past, we have carried preclinical drug examination by testing new synthesized compounds for companies such as Institute of Organic Synthesis (Latvia) and Karo-Bio (Sweden). Together with colleagues from 11^thUniversity of Paris (France), SUNY Upstate Medical University (Syracuse, NY, USA) and KUL (Belgium) we perform electrophysiology studies of intracellular signaling of cardiac cell/heart viability, arrhythmogenesis and other properties under stress conditions. These allow developing new bio-markers, new technical strategies as well as new targets of pharmacological drugs that would be acceptable for diseased heart.

 Projects:

1. National Research Programme “Healthy ageing” project “Age-dependent lipid metabolism and cancer cell viability” supported by Lithuanian Research Council grant (SEN-15/2015); 2015-2018; 200.000 Eur.; Principal investigator – Prof. dr. Rimantas Benetis.
2. Researcher teams’ project “Mechanisms of calcium cycling in ischaemic myocardium” supported by Lithuanian Research Council grant (MIP-058/2015); 2015-2017; 95.277 Eur.; Principal investigator – Habil. dr. Jonas Jurevičius.
3. Global grant project “Investigation of T-wave alternants formation mechanisms during ischemia in explanted and in situ heart models” (No. VP1-3.1- ŠMM-07-K-01-121); 2011-2015; 1 597 847 Lt.; Principal investigator – prof. Arkady M. Pertsov, Co-principal investigator – Habil. dr. Jonas Jurevičius.
4. National Complex Programme “Molecular mechanisms of the ischemic heart disease” supported by European Social Fund (Project Code Number VP1-3.1-ŠMM-0.8-K-01-022), 2012-2014, 746.623 Lt.; Principal investigator – dr. Regina Mačianskienė.

 

International collaboration

• Dr. Rodolphe Fischmeister,  Laboratory of Cellular and Molecular Cardiology of Faculty of Pharmacy of 11^th University of Paris, France.
• Dr. Kanigula Mubagwa and, Dr. Karin Sipido,Division of Experimental Cardiac Surgery and Division of Experimental Cardiology, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium.
• Dr. John Starkus. Pacific Biomedical Research Centre of the University of Hawaii, Honolulu, Hawaii, USA.
• Dr. Arkady Pertsov. SUNY Upstate Medical University, Department of Pharmacology; Laboratory of Bioengineering, Syracuse, NY, USA.
• Dr.Lothar A. Blatter & Dr. Giedrius Kanaporis. Department of Physiology & Biophysics, Rush University Medical Center, Chicago, USA.

 

Other important information

In 2009, habil.dr.. Jonas Jurevičius and dr. Arvydas V. Skeberdis  (former member of the laboratory) were awarded with Lithuanian National Price for Science.

  

Main publications (2017-2013):

2017 -2016 

1. Spectral characteristics of voltage-sensitive indocyanine green fluorescence in the heart / Regina Mačianskienė, Mantė Almanaitytė, Rimantas Treinys, Antanas Navalinskas, Rimantas Benetis, Jonas Jurevičius // Scientific reports. London: Nature Publishing Group. ISSN 2045-2322. 2017, vol. 7, no. 1, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; 1. Internet access: 
2. Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome / Kasper Thorsen, Vibeke S. Dam, Kasper Kjaer-Sorensen, Lisbeth N. Pedersen, V. Arvydas Skeberdis, Jonas Jurevičius, Rimantas Treinys, Ida M.B.S. Petersen, Morten S. Nielsen, Claus Oxvig, J. Preben Morth, Vladimir V. Matchkov, Christian Aalkjær, Henning Bundgaard, Henrik K. Jensen // Nature communications. London: Nature Publishing Group. ISSN 2041-1723. 2017, vol. 8, no. 1, p. 1-10. Science Citation Index Expanded (Web of Science); MEDLINE; DOAJ; 0.529.  Internet access.:
3. Modulation of human cardiac TRPM7 current by extracellular acidic pH depends upon extracellular concentrations of divalent cations / Regina Mačianskienė, Mantė Almanaitytė, Aistė Jekabsone, Kanigula Mubagwa // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2017, vol. 12, no. 1, p. 1-19.Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; AGRICOLA; 0.866. Internet access :
4. Metabolic inhibition reduces cardiac L-type Ca2+ channel current due to acidification caused by ATP hydrolysis / Giedrius Kanaporis, Rimantas Treinys, Rodolphe Fischmeister, Jonas Jurevičius // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2017, vol. 12, no. 8, p. 1-17.Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; AGRICOLA; 0.866. Internet access :
5. Differences in the control of basal L-type Ca2+ current by the cyclic AMP signaling cascade in frog, rat, and human cardiac myocytes / Rimantas Treinys, Andrius Bogdelis, Lina Rimkutė, Jonas Jurevičius, Vytenis Arvydas Skeberdis // Journal of physiological sciences : JPS. Tokyo: Springer. (Original paper). ISSN 1880-6546. 2016, vol. 66, no. 4, p. 327-336. Science Citation Index Expanded (Web of Science); MEDLINE; Chemical Abstracts Service (CAS); CAB International; Scopus; 0.8. Internet access:
6. Voltage-sensitive fluorescence of indocyanine green in the heart / Irma Martišienė, Regina Mačianskienė, Rimantas Treinys, Antanas Navalinskas, Mantė Almanaitytė, Dainius Karčiauskas, Audrius Kučinskas, Ramunė Grigalevičiūtė, Vilma Zigmantaitė, Rimantas Benetis, Jonas Jurevičius // Biophysical journal. Cambridge, MA: Cell Press. ISSN 0006-3495. 2016, vol. 110, no. 3, p. 723-732. Science Citation Index Expanded (Web of Science); MEDLINE; 1.102.  Internet access:

2015 -2013 

1. Exogenous connexin43-expressing autologous skeletal myoblasts ameliorate mechanical function and electrical activity of the rabbit heart after experimental infarction / Antanavičiūtė I, Ereminienė E, Vysockas V, Račkauskas M, Skipskis V, Rysevaitė K, Treinys R, Benetis R, Jurevičius J, Skeberdis VA // International journal of experimental pathology. Oxford, OX: Blackwell Scientific Publications. (Original article). ISSN 0959-9673. 2015, vol. 96, no. 1, p. 42-53. Science Citation Index Expanded (Web of Science); MEDLINE; Index Veterinarius; CAB Abstracts® (CABI); 1.342. Internet access:
2. Evolution of action potential alternans in rabbit heart during acute regional ischemia / Martišienė I, Jurevičius J, Vosyliūtė R, Navalinskas A, Treinys R, Mačianskienė R, Benetis R, Matiukas A, Pertsov AM // BioMed research international. New York: Hindawi Publishing Corporation. (Research article). ISSN 2314-6133. 2015, vol. 2015, p. 1-12. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 1.1.  Internet access:
3. Evaluation of excitation propagation in the rabbit heart: optical mapping and transmural microelectrode recordings / Regina Mačianskienė, Irma Martišienė, Antanas Navalinskas, Rūta Vosyliūtė, Rimantas Treinys, Birutė Vaidelytė, Rimantas Benetis, Jonas Jurevičius // PLoS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2015, vol. 10, no. 4, p. 1-18. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Chemical Abstracts Service (CAS); AGRICOLA; PyscINFO; Zoological Records; DOAJ; 0.875. Internet access :
4. The Role of external Ca(2+) in the action of Ca(2+) - channel agonists and antagonists on isolated human thoracic arteries / Garaliene V, Barsys V, Giedraitis S, Benetis R, Krauze A // Journal of physiology and pharmacology. Krakow: Polish Physiological Society. (Original article). ISSN 0867-5910. 2014, vol. 65, no. 1, p. 25-31. Science Citation Index Expanded (Web of Science); MEDLINE; 0.4. Internet access :
5. β3-adrenergic regulation of L-Type Ca2+ current and force of contraction in human ventricle / Treinys R, Zablockaitė D, Gendvilienė V, Jurevičius J, Skeberdis VA // Journal of membrane biology. New York: Springer. ISSN 0022-2631. 2014, vol. 247, iss. 4, p. 309-318. Science Citation Index Expanded (Web of Science); MEDLINE; 0.6.  Internet access:
6. DRG axon elongation and growth cone collapse rate induced by Sema3A are differently dependent on NGF concentration / Kaselis A, Treinys R, Vosyliūtė R, Satkauskas S // Cellular and molecular neurobiology. New York: Kluwer Academic/Plenum Publishers. (Original research). ISSN 0272-4340. 2014, vol. 34, no. 2, p. 289-296. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; AGRICOLA; CAB Abstracts; 0.354.  Internet access:
7.  R-Type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse / Treinys R, Kaselis A, Jover E, Bagnard D, Satkauskas S // PLoS One. San Francisco: Public Library of Science. ISSN 1932-6203. 2014, vol. 9, no. 7, p. 1-14. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; AGRICOLA; PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; DOAJ; 0.4.  Internet access:
8. The Cardiac atrial appendage stem cell: a new and promising candidate for myocardial repair / Koninckx R, Daniëls A, Windmolders S, Mees U, Macianskiene R, Mubagwa K, Steels P, Jamaer L, Dubois J, Robic B, Hendrikx M, Rummens JL, Hensen K // Cardiovascular research. Oxford: Oxford Journals. ISSN 0008-6363. 2013, vol. 97, no. 3, p. 413-423. Science Citation Index Expanded (Web of Science); MEDLINE; 0.154.  Internet access:

 

Laboratory of Cardiac Pathology

 

Dalia Pangonytė prof. habil..dr.  

Head of laboratory, Head researcher           

 tel.302890,e-mail: dalia.pangonyte@lsmuni.lt

 

  Personnel:

 Vitalija Bunevičienė,Junior researcher

 Lina Utkienė, Junior researcher

 Zita Stanionienė, Senior engineer programmer

 Jūratė Virginija Šmitaitė, preparator

 Renata Valevičienė, Senior laboratory assistant

 Jūratė Dedelienė, Laboratory assistant

 Meilutė Marija Navickienė, Laboratory assistant

 

Main publications (2017-2014):

1. Gyvytė, Ugnė; Juzėnas, Simonas; Šaltenienė, Violeta; Kupčinskas, Juozas; Poškienė, Lina; Kučinskas, Laimutis; Jarmalaitė, Sonata; Stuopelyte, Kristina; Steponaitienė, Rūta; Hemmrich-Stanisak, Georg; Hübenthal, Matthias; Link, Alexander; Franke, Sabine; Franke, Andre; Pangonytė, Dalia; Lesauskaitė, Vaiva; Kupčinskas, Limas; Skiecevičienė, Jurgita. MiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing /  // Oncotarget. Albany, N.Y.: Impact Journals. ISSN 1949-2553. 2017, vol. 8 no. 23, p. 37225-37238. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; 0.351. Internet access: 
2. Ulozas, Virgilijus; Liutkevičius, Vykintas; Pangonytė, Dalia; Lesauskaitė, Vaiva. Characteristics of expression of matrix metalloproteinases (MMP-2 and MMP-9) in glottic squamous cell carcinoma and benign vocal fold lesions  // Clinical and experimental otorhinolaryngology. Seoul: Korean Society of Otorhinolaryngology-Head and Neck Surgery. (Original article). ISSN 1976-8710. 2015, vol. 8, no. 1, p. 57-64.Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; Synapse; 0.707.  Internet access:
3. Lesauskaitė, Vaiva; Šepetienė, Ramunė; Jarienė, Giedrė; Patamsytė, Vaiva; Žukovas, Giedrius; Grabauskytė, Ingrida; Stanionienė, Zita; Širmenis, Raimondas; Benetis, Rimantas. FBN1 polymorphisms in patients with the dilatative pathology of the ascending thoracic aorta  // European journal of cardio-thoracic surgery. Kidlington, Oxford, UK: Elsevier Science. ISSN 1010-7940. 2015, vol. 47, no. 4, p. e124-e130.  Science Citation Index Expanded (Web of Science); MEDLINE; 1.556. Internet access: 
4. Šepetienė, Ramunė; Patamsytė, Vaiva; Žukovas, Giedrius; Jarienė, Giedrė; Stanionienė, Zita; Benetis, Rimantas; Lesauskaitė, Vaiva. Blood plasma TGF- β1 concentration in sporadic dilatative pathology of ascending aorta: more questions than answers // PloS One. San Francisco: Public Library of Science. (Research article). ISSN 1932-6203. 2015, vol. 10, no. 6, p. 1-7. Science Citation Index Expanded (Web of Science); MEDLINE; Scopus; DOAJ; Chemical Abstracts Service (CAS); AGRICOLA; PyscINFO; Zoological Records; FSTA (Food Science and Technology Abstracts); GeoRef; 1.485. Internet access:
5. Šepetienė, Ramunė; Patamsytė, Vaiva; Žukovas, Giedrius; Jarienė, Giedrė; Stanionienė, Zita; Benetis, Rimantas; Tamošiūnas, Abdonas; Lesauskaitė, Vaiva. Association between fibrillin1 polymorphisms (rs2118181, rs10519177) and transforming growth factor β1 concentration in human plasma // Molecular medicine. Manhasset, NY: Feinstein Institute for Medical Research. ISSN 1076-1551. 2015, vol. 21, p. 735-738. Science Citation Index Expanded (Web of Science); MEDLINE; 1.516. Internet access:
6. Smalinskienė, Alina; Savickienė, Nijolė; Žitkevičius, Virgilijus; Pangonytė, Dalia; Sadauskienė, Ilona; Kašauskas, Artūras; Ivanov, Leonid; Lesauskaitė, Vaiva; Savickas, Arūnas; Rodovičius, Hiliaras. Effect of Acanthopanax senticosus on the accumulation of cadmium and on the immune response of spleen cells // Journal of toxicology and environmental health. Part A. Philadelphia: Taylor & Francis. ISSN 1528-7394. 2014, vol. 77, no. 21, p. 1311-1318. Science Citation Index Expanded (Web of Science); MEDLINE; CAB Abstracts; 0.52. Internet access :